CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017680
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Periphilin-1 
Protein Synonyms/Alias
 Gastric cancer antigen Ga50 
Gene Name
 PPHLN1 
Gene Synonyms/Alias
 HSPC206; HSPC232 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
37LVNIVPKKPPLLDRPubiquitination[1]
227KPSRLTEKELAEAASubiquitination[1]
235ELAEAASKWAAEKLEacetylation[2]
240ASKWAAEKLEKSDESacetylation[2]
240ASKWAAEKLEKSDESubiquitination[1]
299KAIASKTKEIEQVYRubiquitination[1]
328EKDPSLEKSIQFALRubiquitination[1, 3, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Involved in epithelial differentiation and contributes to epidermal integrity and barrier formation. 
Sequence Annotation
 MOTIF 103 109 Nuclear localization signal (Potential).
 MOD_RES 110 110 Phosphoserine.
 MOD_RES 133 133 Phosphoserine.
 MOD_RES 140 140 Phosphoserine.
 MOD_RES 155 155 Phosphoserine (By similarity).
 MOD_RES 161 161 Phosphoserine.
 MOD_RES 167 167 Phosphoserine.
 MOD_RES 197 197 Phosphoserine.
 MOD_RES 205 205 Phosphoserine.
 MOD_RES 235 235 N6-acetyllysine.
 MOD_RES 240 240 N6-acetyllysine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Keratinization; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 458 AA 
Protein Sequence
MWSEGRYEYE RIPRERAPPR SHPSDGYNRL VNIVPKKPPL LDRPGEGSYN RYYSHVDYRD 60
YDEGRSFSHD RRSGPPHRGD ESGYRWTRDD HSASRQPEYR DMRDGFRRKS FYSSHYARER 120
SPYKRDNTFF RESPVGRKDS PHSRSGSSVS SRSYSPERSK SYSFHQSQHR KSVRPGASYK 180
RQNEGNPERD KERPVQSLKT SRDTSPSSGS AVSSSKVLDK PSRLTEKELA EAASKWAAEK 240
LEKSDESNLP EISEYEAGST APLFTDQPEE PESNTTHGIE LFEDSQLTTR SKAIASKTKE 300
IEQVYRQDCE TFGMVVKMLI EKDPSLEKSI QFALRQNLHE IESAGQTWQQ VPPVRNTEMD 360
HDGTPENEGE ETAQSAPQPP QAPQPLQPRK KRVRRTTQLR RTTGAPDITW GMLKKTTQEA 420
ERILLRTQTP FTPENLFLAM LSVVHCNSRK DVKPENKQ 458 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0031424; P:keratinization; IEA:UniProtKB-KW. 
Interpro
  
Pfam
  
SMART
  
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PRINTS