UniProt Accession

 ADH7_MOUSE; Q64437 

Genbank Protein ID

 U20257; U76734; U76728; U76729; U76730; U76727; U76731; U76733; U76732; AC079682 

Genbank Nucleotide ID

 AAA76735.1; AAC53124.1; AAC53124.1; AAC53124.1; AAC53124.1; AAC53124.1; AAC53124.1; AAC53124.1; AAC53124.1 

Protein Name

 Alcohol dehydrogenase class 4 mu/sigma chain 

Protein Synonyms/Alias

 ADH-C2; Alcohol dehydrogenase 7; Alcohol dehydrogenase class IV mu/sigma chain; Gastric alcohol dehydrogenase; Retinol dehydrogenase 

Gene Name

 Adh7 

Gene Synonyms/Alias

 Adh-3; Adh3 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
338	LVTEFLEKKFDLDQL	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. 

Sequence Annotation

 NP_BIND 199 204 NAD (By similarity).
 NP_BIND 292 294 NAD (By similarity).
 METAL 47 47 Zinc 1; catalytic (By similarity).
 METAL 68 68 Zinc 1; catalytic (By similarity).
 METAL 98 98 Zinc 2 (By similarity).
 METAL 101 101 Zinc 2 (By similarity).
 METAL 104 104 Zinc 2 (By similarity).
 METAL 112 112 Zinc 2 (By similarity).
 METAL 174 174 Zinc 1; catalytic (By similarity).
 BINDING 223 223 NAD (By similarity).
 BINDING 228 228 NAD (By similarity).
 BINDING 369 369 NAD (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Metal-binding; NAD; Oxidoreductase; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 374 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005576; C:extracellular region; IEA:Compara.
 GO:0005622; C:intracellular; IDA:MGI.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0004022; F:alcohol dehydrogenase (NAD) activity; IDA:MGI.
 GO:0004024; F:alcohol dehydrogenase activity, zinc-dependent; IEA:Compara.
 GO:0004031; F:aldehyde oxidase activity; IEA:Compara.
 GO:0035276; F:ethanol binding; IEA:Compara.
 GO:0019841; F:retinol binding; IEA:Compara.
 GO:0004745; F:retinol dehydrogenase activity; IDA:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006068; P:ethanol catabolic process; IMP:MGI.
 GO:0006069; P:ethanol oxidation; IEA:Compara.
 GO:1900116; P:extracellular negative regulation of signal transduction; IEA:Compara.
 GO:0010430; P:fatty acid omega-oxidation; IEA:Compara.
 GO:0009617; P:response to bacterium; IEA:Compara.
 GO:0045471; P:response to ethanol; IEA:Compara.
 GO:0042573; P:retinoic acid metabolic process; IMP:MGI.
 GO:0042572; P:retinol metabolic process; IMP:MGI. 

Interpro

 IPR013149; ADH_C.
 IPR013154; ADH_GroES-like.
 IPR002085; ADH_SF_Zn-type.
 IPR002328; ADH_Zn_CS.
 IPR011032; GroES-like.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF08240; ADH_N
 PF00107; ADH_zinc_N 

SMART

  

PROSITE

 PS00059; ADH_ZINC 

PRINTS