UniProt Accession

 BAX_HUMAN; Q07812; A8K4W1; P55269; Q07814; Q07815; Q8WZ49; Q9NR76; Q9NYG7; Q9UCZ6; Q9UCZ7; Q9UQD6 

Genbank Protein ID

 L22473; L22474; L22475; U19599; AF007826; AF247393; AJ417988; AF250190; AK291076; AY217036; CH471177; CH471177; BC014175 

Genbank Nucleotide ID

 AAA03619.1; AAA03620.1; AAA03621.1; AAC50142.1; AAD22706.1; AAF71267.1; CAD10744.1; AAF82094.1; BAF83765.1; AAO22992.1; EAW52418.1; EAW52417.1; AAH14175.1 

Protein Name

 Apoptosis regulator BAX 

Protein Synonyms/Alias

 Bcl-2-like protein 4; Bcl2-L-4 

Gene Name

 BAX 

Gene Synonyms/Alias

 BCL2L4 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
21	TSSEQIMKTGALLLQ	ubiquitination	[1, 2, 3]
57	VPQDASTKKLSECLK	ubiquitination	[2, 3]
123	FASKLVLKALCTKVP	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. 

Sequence Annotation

 MOTIF 59 73 BH3.
 MOTIF 98 118 BH1.
 MOTIF 150 165 BH2.
 MOD_RES 1 1 N-acetylmethionine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Apoptosis; Complete proteome; Cytoplasm; Host-virus interaction; Membrane; Mitochondrion; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Tumor suppressor. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 192 AA 

Protein Sequence

Gene Ontology

 GO:0097136; C:Bcl-2 family protein complex; IDA:UniProtKB.
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0005789; C:endoplasmic reticulum membrane; IDA:HGNC.
 GO:0005741; C:mitochondrial outer membrane; TAS:Reactome.
 GO:0005757; C:mitochondrial permeability transition pore complex; IDA:HGNC.
 GO:0005634; C:nucleus; IMP:UniProtKB.
 GO:0051434; F:BH3 domain binding; IDA:UniProtKB.
 GO:0015267; F:channel activity; IDA:BHF-UCL.
 GO:0008289; F:lipid binding; IDA:HGNC.
 GO:0042803; F:protein homodimerization activity; IDA:HGNC.
 GO:0008635; P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; IDA:HGNC.
 GO:0006309; P:apoptotic DNA fragmentation; IMP:HGNC.
 GO:0001783; P:B cell apoptotic process; IDA:HGNC.
 GO:0001782; P:B cell homeostasis; IEA:Compara.
 GO:0002358; P:B cell homeostatic proliferation; IEA:Compara.
 GO:0002352; P:B cell negative selection; IEA:Compara.
 GO:0001974; P:blood vessel remodeling; IEA:Compara.
 GO:0071310; P:cellular response to organic substance; IEA:Compara.
 GO:0034644; P:cellular response to UV; IEA:Compara.
 GO:0021987; P:cerebral cortex development; IEA:Compara.
 GO:0006922; P:cleavage of lamin involved in execution phase of apoptosis; IMP:HGNC.
 GO:0045136; P:development of secondary sexual characteristics; IEA:Compara.
 GO:0010248; P:establishment or maintenance of transmembrane electrochemical gradient; IDA:HGNC.
 GO:0097191; P:extrinsic apoptotic signaling pathway; IDA:BHF-UCL.
 GO:0009566; P:fertilization; IEA:Compara.
 GO:0007281; P:germ cell development; IEA:Compara.
 GO:0035234; P:germ cell programmed cell death; IEA:Compara.
 GO:0006687; P:glycosphingolipid metabolic process; IEA:Compara.
 GO:0048873; P:homeostasis of number of cells within a tissue; IEA:Compara.
 GO:0021854; P:hypothalamus development; IEA:Compara.
 GO:0006917; P:induction of apoptosis; NAS:UniProtKB.
 GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IMP:UniProtKB.
 GO:0001822; P:kidney development; IEA:Compara.
 GO:0035108; P:limb morphogenesis; IEA:Compara.
 GO:0043653; P:mitochondrial fragmentation involved in apoptotic process; IDA:HGNC.
 GO:0008053; P:mitochondrial fusion; IDA:HGNC.
 GO:0002262; P:myeloid cell homeostasis; IEA:Compara.
 GO:0048147; P:negative regulation of fibroblast proliferation; IEA:Compara.
 GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Compara.
 GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; IEA:Compara.
 GO:0032091; P:negative regulation of protein binding; IDA:UniProtKB.
 GO:0051402; P:neuron apoptotic process; IEA:Compara.
 GO:0001764; P:neuron migration; IEA:Compara.
 GO:0030264; P:nuclear fragmentation involved in apoptotic nuclear change; IMP:HGNC.
 GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Compara.
 GO:0001541; P:ovarian follicle development; IEA:Compara.
 GO:0060058; P:positive regulation of apoptotic process involved in mammary gland involution; IEA:Compara.
 GO:0002904; P:positive regulation of B cell apoptotic process; IEA:Compara.
 GO:0048087; P:positive regulation of developmental pigmentation; IEA:Compara.
 GO:1900103; P:positive regulation of endoplasmic reticulum unfolded protein response; IMP:UniProtKB.
 GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IMP:UniProtKB.
 GO:1901030; P:positive regulation of mitochondrial outer membrane permeabilization; TAS:Reactome.
 GO:0043525; P:positive regulation of neuron apoptotic process; IDA:HGNC.
 GO:0032461; P:positive regulation of protein oligomerization; IDA:UniProtKB.
 GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IDA:UniProtKB.
 GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IEA:Compara.
 GO:0048597; P:post-embryonic camera-type eye morphogenesis; IEA:Compara.
 GO:0051260; P:protein homooligomerization; IDA:HGNC.
 GO:0001844; P:protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; IEA:Compara.
 GO:0032471; P:reduction of endoplasmic reticulum calcium ion concentration; IEA:Compara.
 GO:0051726; P:regulation of cell cycle; IEA:Compara.
 GO:0033599; P:regulation of mammary gland epithelial cell proliferation; IEA:Compara.
 GO:0051881; P:regulation of mitochondrial membrane potential; IDA:HGNC.
 GO:0006808; P:regulation of nitrogen utilization; IEA:Compara.
 GO:0043497; P:regulation of protein heterodimerization activity; IPI:HGNC.
 GO:0043496; P:regulation of protein homodimerization activity; IDA:HGNC.
 GO:0001836; P:release of cytochrome c from mitochondria; IDA:HGNC.
 GO:0032976; P:release of matrix enzymes from mitochondria; IDA:HGNC.
 GO:0001101; P:response to acid; IEA:Compara.
 GO:0048678; P:response to axon injury; IEA:Compara.
 GO:0006974; P:response to DNA damage stimulus; IEA:Compara.
 GO:0010332; P:response to gamma radiation; IEA:Compara.
 GO:0009651; P:response to salt stress; IEA:Compara.
 GO:0009636; P:response to toxic substance; IDA:HGNC.
 GO:0060041; P:retina development in camera-type eye; IEA:Compara.
 GO:1990009; P:retinal cell apoptotic process; IMP:HGNC.
 GO:0046666; P:retinal cell programmed cell death; IEA:Compara.
 GO:0060011; P:Sertoli cell proliferation; IEA:Compara.
 GO:0048515; P:spermatid differentiation; IEA:Compara.
 GO:0001777; P:T cell homeostatic proliferation; IEA:Compara.
 GO:0006927; P:transformed cell apoptotic process; IMP:HGNC.
 GO:0060068; P:vagina development; IEA:Compara.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 

Interpro

 IPR026304; BAX.
 IPR002475; Bcl2-like.
 IPR020717; Bcl2_BH1_motif_CS.
 IPR020726; Bcl2_BH2_motif_CS.
 IPR020728; Bcl2_BH3_motif_CS.
 IPR026298; Blc2_fam. 

Pfam

 PF00452; Bcl-2 

SMART

  

PROSITE

 PS50062; BCL2_FAMILY
 PS01080; BH1
 PS01258; BH2
 PS01259; BH3 

PRINTS

 PR01862; BCL2FAMILY.