| Tag | Content |
|---|
| CPLM ID | CPLM-004537 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Zinc finger protein 8 |
Protein Synonyms/Alias | Zinc finger protein HF.18 |
Gene Name | ZNF8 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 174 | PVQDQGYKTLRLREN | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | May be involved in transcriptional regulation. |
Sequence Annotation | DOMAIN 25 96 KRAB.
ZN_FING 257 279 C2H2-type 1.
ZN_FING 285 307 C2H2-type 2.
ZN_FING 313 335 C2H2-type 3.
ZN_FING 341 363 C2H2-type 4.
ZN_FING 369 391 C2H2-type 5.
ZN_FING 397 419 C2H2-type 6.
ZN_FING 467 489 C2H2-type 7. |
Keyword | Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 575 AA |
Protein Sequence | MDPEDEGVAG VMSVGPPAAR LQEPVTFRDV AVDFTQEEWG QLDPTQRILY RDVMLETFGH 60
LLSIGPELPK PEVISQLEQG TELWVAERGT TQGCHPAWEP RSESQASRKE EGLPEEEPSH 120
VTGREGFPTD APYPTTLGKD RECQSQSLAL KEQNNLKQLE FGLKEAPVQD QGYKTLRLRE 180
NCVLSSSPNP FPEISRGEYL YTYDSQITDS EHNSSLVSQQ TGSPGKQPGE NSDCHRDSSQ 240
AIPITELTKS QVQDKPYKCT DCGKSFNHNA HLTVHKRIHT GERPYMCKEC GKAFSQNSSL 300
VQHERIHTGD KPYKCAECGK SFCHSTHLTV HRRIHTGEKP YECQDCGRAF NQNSSLGRHK 360
RTHTGEKPYT CSVCGKSFSR TTCLFLHLRT HTEERPYECN HCGKGFRHSS SLAQHQRKHA 420
GEKPFECRQR LIFEQTPALT KHEWTEALGC DPPLSQDERT HRSDRPFKCN QCGKCFIQSS 480
HLIRHQITHT REEQPHGRSR RREQSSSRNS HLVQHQHPNS RKSSAGGAKA GQPESRALAL 540
FDIQKIMQEK NPVHVIGVEE PSVGASMLFD IREST 575 |
Gene Ontology | GO:0005634; C:nucleus; NAS:UniProtKB. GO:0003677; F:DNA binding; NAS:UniProtKB. GO:0008270; F:zinc ion binding; NAS:UniProtKB. GO:0030509; P:BMP signaling pathway; IEA:Compara. GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara. GO:0006355; P:regulation of transcription, DNA-dependent; NAS:UniProtKB. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |