CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017949
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Kelch domain-containing protein 4 
Protein Synonyms/Alias
  
Gene Name
 KLHDC4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
49HFQTLDAKRTQTVELubiquitination[1]
169TKTWEQVKSTGGPSGubiquitination[2]
252VVYGGYSKQRVKKDVubiquitination[2]
292RMNPSGVKPTPRSGFubiquitination[2]
348RWFEGQLKGPKSEKKubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
 REPEAT 77 129 Kelch 1.
 REPEAT 133 187 Kelch 2.
 REPEAT 188 241 Kelch 3.
 REPEAT 243 289 Kelch 4.
 REPEAT 308 361 Kelch 5.
 REPEAT 443 494 Kelch 6.
 MOD_RES 413 413 Phosphoserine.
 MOD_RES 418 418 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Kelch repeat; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 520 AA 
Protein Sequence
MGKKGKKEKK GRGAEKTAAK MEKKVSKRSR KEEEDLEALI AHFQTLDAKR TQTVELPCPP 60
PSPRLNASLS VHPEKDELIL FGGEYFNGQK TFLYNELYVY NTRKDTWTKV DIPSPPPRRC 120
AHQAVVVPQG GGQLWVFGGE FASPNGEQFY HYKDLWVLHL ATKTWEQVKS TGGPSGRSGH 180
RMVAWKRQLI LFGGFHESTR DYIYYNDVYA FNLDTFTWSK LSPSGTGPTP RSGCQMSVTP 240
QGGIVVYGGY SKQRVKKDVD KGTRHSDMFL LKPEDGREDK WVWTRMNPSG VKPTPRSGFS 300
VAMAPNHQTL FFGGVCDEEE EESLSGEFFN DLYFYDATRN RWFEGQLKGP KSEKKKRRRG 360
RKEEPEGGSR PACGGAGTQG PVQLVKEVVA EDGTVVTIKQ VLTAPGSAGQ PRSEDEDSLE 420
EAGSPAPGPC PRSNAMLAVK HGVLYVYGGM FEAGDRQVTL SDLHCLDLHR MEAWKALVEM 480
DPETQEWLEE TDSEEDSEEV EGAEGGVDDE DSGEESGAED 520 
Gene Ontology
  
Interpro
 IPR015915; Kelch-typ_b-propeller.
 IPR011498; Kelch_2. 
Pfam
 PF07646; Kelch_2 
SMART
  
PROSITE
  
PRINTS