CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004364
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Vascular endothelial growth factor A 
Protein Synonyms/Alias
 VEGF-A; Vascular permeability factor; VPF 
Gene Name
 VEGFA 
Gene Synonyms/Alias
 VEGF 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
147EKKSVRGKGKGQKRKacetylation[1, 2]
149KSVRGKGKGQKRKRKacetylation[1, 2]
152RGKGKGQKRKRKKSRacetylation[1]
154KGKGQKRKRKKSRYKacetylation[2]
Reference
 [1] Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
 Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y.
 Mol Cell. 2006 Aug;23(4):607-18. [PMID: 16916647]
 [2] Proteome-wide prediction of acetylation substrates.
 Basu A, Rose KL, Zhang J, Beavis RC, Ueberheide B, Garcia BA, Chait B, Zhao Y, Hunt DF, Segal E, Allis CD, Hake SB.
 Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13785-90. [PMID: 19666589] 
Functional Description
 Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. 
Sequence Annotation
 CARBOHYD 101 101 N-linked (GlcNAc...).
 DISULFID 52 94
 DISULFID 77 77 Interchain.
 DISULFID 83 128
 DISULFID 86 86 Interchain.
 DISULFID 87 130  
Keyword
 3D-structure; Alternative initiation; Alternative promoter usage; Alternative splicing; Angiogenesis; Complete proteome; Developmental protein; Differentiation; Direct protein sequencing; Disulfide bond; Glycoprotein; Growth factor; Heparin-binding; Mitogen; Reference proteome; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 232 AA 
Protein Sequence
MNFLLSWVHW SLALLLYLHH AKWSQAAPMA EGGGQNHHEV VKFMDVYQRS YCHPIETLVD 60
IFQEYPDEIE YIFKPSCVPL MRCGGCCNDE GLECVPTEES NITMQIMRIK PHQGQHIGEM 120
SFLQHNKCEC RPKKDRARQE KKSVRGKGKG QKRKRKKSRY KSWSVYVGAR CCLMPWSLPG 180
PHPCGPCSER RKHLFVQDPQ TCKCSCKNTD SRCKARQLEL NERTCRCDKP RR 232 
Gene Ontology
 GO:0009986; C:cell surface; IDA:BHF-UCL.
 GO:0005615; C:extracellular space; IDA:UniProtKB.
 GO:0016020; C:membrane; IEA:InterPro.
 GO:0031093; C:platelet alpha granule lumen; TAS:Reactome.
 GO:0005578; C:proteinaceous extracellular matrix; NAS:UniProtKB.
 GO:0042056; F:chemoattractant activity; IDA:UniProtKB.
 GO:0005125; F:cytokine activity; IDA:BHF-UCL.
 GO:0050840; F:extracellular matrix binding; IC:BHF-UCL.
 GO:0001968; F:fibronectin binding; IDA:BHF-UCL.
 GO:0008083; F:growth factor activity; IDA:BHF-UCL.
 GO:0008201; F:heparin binding; IDA:UniProtKB.
 GO:0046982; F:protein heterodimerization activity; IDA:MGI.
 GO:0042803; F:protein homodimerization activity; ISS:BHF-UCL.
 GO:0032147; P:activation of protein kinase activity; IDA:BHF-UCL.
 GO:0002575; P:basophil chemotaxis; IDA:UniProtKB.
 GO:0048593; P:camera-type eye morphogenesis; ISS:BHF-UCL.
 GO:0048739; P:cardiac muscle fiber development; ISS:BHF-UCL.
 GO:0060948; P:cardiac vascular smooth muscle cell development; ISS:BHF-UCL.
 GO:0048469; P:cell maturation; ISS:BHF-UCL.
 GO:0002042; P:cell migration involved in sprouting angiogenesis; IDA:BHF-UCL.
 GO:0060982; P:coronary artery morphogenesis; ISS:BHF-UCL.
 GO:0003169; P:coronary vein morphogenesis; ISS:BHF-UCL.
 GO:0071542; P:dopaminergic neuron differentiation; ISS:BHF-UCL.
 GO:0035767; P:endothelial cell chemotaxis; IDA:BHF-UCL.
 GO:0030855; P:epithelial cell differentiation; ISS:BHF-UCL.
 GO:0042462; P:eye photoreceptor cell development; ISS:BHF-UCL.
 GO:0040007; P:growth; ISS:BHF-UCL.
 GO:0001701; P:in utero embryonic development; ISS:BHF-UCL.
 GO:0050930; P:induction of positive chemotaxis; IDA:UniProtKB.
 GO:0001822; P:kidney development; ISS:BHF-UCL.
 GO:0007595; P:lactation; ISS:BHF-UCL.
 GO:0030324; P:lung development; ISS:BHF-UCL.
 GO:0036303; P:lymph vessel morphogenesis; ISS:BHF-UCL.
 GO:0030225; P:macrophage differentiation; IDA:DFLAT.
 GO:0060749; P:mammary gland alveolus development; ISS:BHF-UCL.
 GO:0007498; P:mesoderm development; ISS:BHF-UCL.
 GO:0030224; P:monocyte differentiation; IDA:DFLAT.
 GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
 GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0003151; P:outflow tract morphogenesis; ISS:BHF-UCL.
 GO:0001541; P:ovarian follicle development; ISS:BHF-UCL.
 GO:0001569; P:patterning of blood vessels; ISS:BHF-UCL.
 GO:0030168; P:platelet activation; TAS:Reactome.
 GO:0002576; P:platelet degranulation; TAS:Reactome.
 GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; ISS:BHF-UCL.
 GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
 GO:0090050; P:positive regulation of cell migration involved in sprouting angiogenesis; IDA:BHF-UCL.
 GO:0038091; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway; IDA:BHF-UCL.
 GO:0032793; P:positive regulation of CREB transcription factor activity; IDA:BHF-UCL.
 GO:0038033; P:positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway; IDA:BHF-UCL.
 GO:0001938; P:positive regulation of endothelial cell proliferation; IDA:UniProtKB.
 GO:0051894; P:positive regulation of focal adhesion assembly; IDA:UniProtKB.
 GO:1901727; P:positive regulation of histone deacetylase activity; IDA:BHF-UCL.
 GO:0002687; P:positive regulation of leukocyte migration; TAS:BHF-UCL.
 GO:0043406; P:positive regulation of MAP kinase activity; IDA:BHF-UCL.
 GO:0060754; P:positive regulation of mast cell chemotaxis; IDA:UniProtKB.
 GO:0002053; P:positive regulation of mesenchymal cell proliferation; ISS:BHF-UCL.
 GO:0002052; P:positive regulation of neuroblast proliferation; ISS:BHF-UCL.
 GO:1900745; P:positive regulation of p38MAPK cascade; IDA:UniProtKB.
 GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IDA:BHF-UCL.
 GO:1900086; P:positive regulation of peptidyl-tyrosine autophosphorylation; IDA:BHF-UCL.
 GO:0031954; P:positive regulation of protein autophosphorylation; IDA:UniProtKB.
 GO:0031334; P:positive regulation of protein complex assembly; IDA:UniProtKB.
 GO:0090037; P:positive regulation of protein kinase C signaling cascade; IDA:BHF-UCL.
 GO:0002092; P:positive regulation of receptor internalization; IDA:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0061419; P:positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; IMP:BHF-UCL.
 GO:0030949; P:positive regulation of vascular endothelial growth factor receptor signaling pathway; IDA:BHF-UCL.
 GO:0043117; P:positive regulation of vascular permeability; IDA:UniProtKB.
 GO:0031077; P:post-embryonic camera-type eye development; ISS:BHF-UCL.
 GO:0060319; P:primitive erythrocyte differentiation; ISS:BHF-UCL.
 GO:0008360; P:regulation of cell shape; IDA:BHF-UCL.
 GO:0043129; P:surfactant homeostasis; ISS:BHF-UCL.
 GO:0035148; P:tube formation; IDA:UniProtKB.
 GO:0001570; P:vasculogenesis; TAS:UniProtKB. 
Interpro
 IPR000072; PD_growth_factor.
 IPR023581; PD_growth_factor_CS. 
Pfam
 PF00341; PDGF 
SMART
 SM00141; PDGF 
PROSITE
 PS00249; PDGF_1
 PS50278; PDGF_2 
PRINTS