UniProt Accession

 HDA11_HUMAN; Q96DB2; B4DDK1; Q9H6I7; Q9H6X3; Q9NTC9 

Genbank Protein ID

 AK025426; AK025890; AK293223; AC027124; BC009676; AL137362 

Genbank Nucleotide ID

 BAB15127.1; BAB15272.1; BAG56762.1; AAH09676.1; CAB70712.1 

Protein Name

 Histone deacetylase 11 

Protein Synonyms/Alias

 HD11 

Gene Name

 HDAC11 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
280	ISPAGIVKRDELVFR	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. 

Sequence Annotation

 REGION 14 326 Histone deacetylase.
 ACT_SITE 143 143 By similarity.  

Keyword

 Alternative splicing; Chromatin regulator; Complete proteome; Hydrolase; Nucleus; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 347 AA 

Protein Sequence

Gene Ontology

 GO:0000118; C:histone deacetylase complex; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IDA:LIFEdb.
 GO:0004407; F:histone deacetylase activity; IDA:UniProtKB.
 GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.
 GO:0097372; F:NAD-dependent histone deacetylase activity (H3-K18 specific); IEA:EC.
 GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.
 GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
 GO:0008134; F:transcription factor binding; TAS:UniProtKB.
 GO:0070932; P:histone H3 deacetylation; IEA:GOC.
 GO:0070933; P:histone H4 deacetylation; IEA:GOC.
 GO:0014003; P:oligodendrocyte development; IEA:Compara.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR000286; His_deacetylse.
 IPR023801; His_deacetylse_dom. 

Pfam

 PF00850; Hist_deacetyl 

SMART

  

PROSITE

  

PRINTS

 PR01270; HDASUPER.