CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000205
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Histone deacetylase 1 
Protein Synonyms/Alias
 HD1 
Gene Name
 Hdac1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
74YHSDDYIKFLRSIRPubiquitination[1]
89DNMSEYSKQMQRFNVubiquitination[1]
361NTNEYLEKIKQRLFEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B (By similarity). Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. 
Sequence Annotation
 REGION 9 321 Histone deacetylase.
 ACT_SITE 141 141 By similarity.
 MOD_RES 74 74 N6-acetyllysine (By similarity).
 MOD_RES 220 220 N6-acetyllysine (By similarity).
 MOD_RES 393 393 Phosphoserine.
 MOD_RES 421 421 Phosphoserine.
 MOD_RES 423 423 Phosphoserine.
 MOD_RES 432 432 N6-methylated lysine; by EHMT2 (By
 CROSSLNK 444 444 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 476 476 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Acetylation; Chromatin regulator; Complete proteome; Hydrolase; Isopeptide bond; Methylation; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 482 AA 
Protein Sequence
MAQTQGTKRK VCYYYDGDVG NYYYGQGHPM KPHRIRMTHN LLLNYGLYRK MEIYRPHKAN 60
AEEMTKYHSD DYIKFLRSIR PDNMSEYSKQ MQRFNVGEDC PVFDGLFEFC QLSTGGSVAS 120
AVKLNKQQTD IAVNWAGGLH HAKKSEASGF CYVNDIVLAI LELLKYHQRV LYIDIDIHHG 180
DGVEEAFYTT DRVMTVSFHK YGEYFPGTGD LRDIGAGKGK YYAVNYPLRD GIDDESYEAI 240
FKPVMSKVME MFQPSAVVLQ CGSDSLSGDR LGCFNLTIKG HAKCVEFVKS FNLPMLMLGG 300
GGYTIRNVAR CWTYETAVAL DTEIPNELPY NDYFEYFGPD FKLHISPSNM TNQNTNEYLE 360
KIKQRLFENL RMLPHAPGVQ MQAIPEDAIP EESGDEDEED PDKRISICSS DKRIACEEEF 420
SDSDEEGEGG RKNSSNFKKA KRVKTEDEKE KDPEEKKEVT EEEKTKEEKP EAKGVKEEVK 480
LA 482 
Gene Ontology
 GO:0005737; C:cytoplasm; TAS:UniProtKB.
 GO:0000792; C:heterochromatin; IDA:MGI.
 GO:0043025; C:neuronal cell body; IDA:MGI.
 GO:0000790; C:nuclear chromatin; IDA:BHF-UCL.
 GO:0016581; C:NuRD complex; IDA:MGI.
 GO:0005667; C:transcription factor complex; IDA:UniProtKB.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0003677; F:DNA binding; IDA:MGI.
 GO:0004407; F:histone deacetylase activity; IDA:UniProtKB.
 GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.
 GO:0097372; F:NAD-dependent histone deacetylase activity (H3-K18 specific); IEA:EC.
 GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.
 GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI.
 GO:0003714; F:transcription corepressor activity; IDA:MGI.
 GO:0008134; F:transcription factor binding; TAS:UniProtKB.
 GO:0042733; P:embryonic digit morphogenesis; IGI:BHF-UCL.
 GO:0007492; P:endoderm development; IDA:MGI.
 GO:0009913; P:epidermal cell differentiation; IGI:BHF-UCL.
 GO:0061029; P:eyelid development in camera-type eye; IGI:BHF-UCL.
 GO:0061198; P:fungiform papilla formation; IGI:BHF-UCL.
 GO:0060789; P:hair follicle placode formation; IGI:BHF-UCL.
 GO:0021766; P:hippocampus development; IGI:MGI.
 GO:0070932; P:histone H3 deacetylation; IEA:GOC.
 GO:0070933; P:histone H4 deacetylation; IEA:GOC.
 GO:0043066; P:negative regulation of apoptotic process; IGI:BHF-UCL.
 GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IGI:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IGI:BHF-UCL.
 GO:0030182; P:neuron differentiation; IGI:MGI.
 GO:0042475; P:odontogenesis of dentin-containing tooth; IGI:BHF-UCL.
 GO:0008284; P:positive regulation of cell proliferation; IGI:BHF-UCL.
 GO:0048714; P:positive regulation of oligodendrocyte differentiation; IGI:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR000286; His_deacetylse.
 IPR003084; His_deacetylse_1.
 IPR023801; His_deacetylse_dom. 
Pfam
 PF00850; Hist_deacetyl 
SMART
  
PROSITE
  
PRINTS
 PR01270; HDASUPER.
 PR01271; HISDACETLASE.