UniProt Accession

 PAHX_MOUSE; O35386; O08527 

Genbank Protein ID

 AF023463; D88670; BC002018 

Genbank Nucleotide ID

 AAB81835.1; BAA19003.1; AAH02018.1 

Protein Name

 Phytanoyl-CoA dioxygenase, peroxisomal 

Protein Synonyms/Alias

 Lupus nephritis-associated peptide 1; Phytanic acid oxidase; Phytanoyl-CoA alpha-hydroxylase; PhyH 

Gene Name

 Phyh 

Gene Synonyms/Alias

 Ln1; Lnap1; Pahx 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
59	VLTLEQRKFYEENGF	acetylation	[1]
59	VLTLEQRKFYEENGF	succinylation	[1]
59	VLTLEQRKFYEENGF	ubiquitination	[2]
108	MRDVALAKQDYMPSD	acetylation	[1]
108	MRDVALAKQDYMPSD	succinylation	[1]
108	MRDVALAKQDYMPSD	ubiquitination	[2]
120	PSDRMVSKIQDFQED	ubiquitination	[2]
218	GTHKGTLKPHDYPKW	acetylation	[3]
224	LKPHDYPKWEGGVNK	ubiquitination	[2]
231	KWEGGVNKMYHGIQD	acetylation	[1]
231	KWEGGVNKMYHGIQD	succinylation	[1]
231	KWEGGVNKMYHGIQD	ubiquitination	[2]
252	RVHLVMEKGDTVFFH	acetylation	[1]
252	RVHLVMEKGDTVFFH	succinylation	[1]
311	VVEMAEKKYGFQGVM	acetylation	[1]
311	VVEMAEKKYGFQGVM	succinylation	[1]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 

Functional Description

 Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA. 

Sequence Annotation

 REGION 175 177 Alpha-ketoglutarate binding (By
 METAL 175 175 Iron (By similarity).
 METAL 177 177 Iron (By similarity).
 METAL 264 264 Iron (By similarity).
 BINDING 120 120 Alpha-ketoglutarate (By similarity).
 BINDING 157 157 Alpha-ketoglutarate (By similarity).
 BINDING 193 193 Alpha-ketoglutarate (By similarity).
 BINDING 266 266 Alpha-ketoglutarate (By similarity).
 BINDING 275 275 Alpha-ketoglutarate (By similarity).  

Keyword

 Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase; Peroxisome; Reference proteome; Transit peptide; Vitamin C. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 338 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005777; C:peroxisome; TAS:MGI.
 GO:0003824; F:catalytic activity; IDA:MGI.
 GO:0048037; F:cofactor binding; IEA:Compara.
 GO:0031418; F:L-ascorbic acid binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:UniProtKB-KW.
 GO:0048244; F:phytanoyl-CoA dioxygenase activity; IEA:EC.
 GO:0001561; P:fatty acid alpha-oxidation; IDA:MGI.
 GO:0006720; P:isoprenoid metabolic process; IEA:Compara.
 GO:0097089; P:methyl-branched fatty acid metabolic process; IEA:Compara. 

Interpro

 IPR008775; Phytyl_CoA_dOase. 

Pfam

 PF05721; PhyH 

SMART

  

PROSITE

  

PRINTS