CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031410
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 cDNA FLJ56176, highly similar to Poly(A) polymerase alpha (EC 2.7.7.19) 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
152FFTSFYDKLKLQEEVubiquitination[1]
376LSKAEWSKLFEAPNFubiquitination[1, 2]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
  
Sequence Annotation
  
Keyword
  
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 761 AA 
Protein Sequence
MLGRRGSDWA VPAPETMPFP VTTQGSQQTQ PPQKHYGITS PISLAAPKET DCVLTQKLIE 60
TLKPFGVFEE EEELQRRILI LGKLNNLVKE WIREISESKN LPQSVIENVG GKIFTFGSYR 120
LGVHTKGADI DALCVAPRHV DRSDFFTSFY DKLKLQEEVK DLRAVEEAFV PVIKLCFDGI 180
EIDILFARLA LQTIPEDLDL RDDSLLKNLD IRCIRSLNGC RVTDEILHLV PNIDNFRLTL 240
RAIKLWAKRH NIYSNILGFL GGVSWAMLVA RTCQLYPNAI ASTLVHKFFL VFSKWEWPNP 300
VLLKQPEECN LNLPVWDPRV NPSDRYHLMP IITPAYPQQN STYNVSVSTR MVMVEEFKQG 360
PAITDEILLS KAEWSKLFEA PNFFQKYKHY IVLLASAPTE KQRLEWVGLV ESKIRILVGS 420
LEKNEFITLA HVNPQSFPAP KENPDKEEFR TMWVIGLVFK KTENSENLSV DLTYDIQSFT 480
DTVYRQAINS KMFEVDMKIA AMHVKRKQLH QLLPNHVLQK KKKHSTEGVK LTALNDSSLD 540
LSMDSDNSMS VPSPTSATKT SPLNSSGSSQ GRNSPAPAVT AASVTNIQAT EVSVPQVNSS 600
ESSGGTSSES IPQTATQPAI SPPPKPTVSR VVSSTRLVNP PPRSSGNAAT SGNAATKIPT 660
PIVGVKRTSS PHKEESPKKT KTEEDETSED ANCLALSGHD KTEAKEQLDT ETSTTQSETI 720
QTAASLLASQ KTSSTDLSDI PALPANPIPV IKNSIKLRLN R 761 
Gene Ontology
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0004652; F:polynucleotide adenylyltransferase activity; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:InterPro.
 GO:0043631; P:RNA polyadenylation; IEA:InterPro. 
Interpro
 IPR002934; Nucleotidyltransferase.
 IPR011068; NuclTrfase_I_C.
 IPR007012; PolA_pol_cen_dom.
 IPR007010; PolA_pol_RNA-bd_dom.
 IPR014492; PolyA_polymerase. 
Pfam
 PF01909; NTP_transf_2
 PF04928; PAP_central
 PF04926; PAP_RNA-bind 
SMART
  
PROSITE
  
PRINTS