CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014754
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 N-acetylgalactosamine kinase 
Protein Synonyms/Alias
 GalNAc kinase; Galactokinase 2 
Gene Name
 Galk2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
252MECRLAAKVLAKHKGubiquitination[1]
327TQDELTFKLYQRAKHubiquitination[1]
447KHSLFATKPGGGALVubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations (By similarity). 
Sequence Annotation
 NP_BIND 139 149 ATP (Potential).
 REGION 49 52 Substrate binding (By similarity).
 REGION 187 190 Substrate binding (By similarity).
 ACT_SITE 190 190 Proton acceptor (By similarity).
 BINDING 49 49 Substrate (By similarity).  
Keyword
 ATP-binding; Complete proteome; Direct protein sequencing; Kinase; Nucleotide-binding; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 458 AA 
Protein Sequence
MAAEDPATRR VQVAEHPRLL KLKEMFNSKF GSTPKFYVRA PGRVNIIGEH IDYCGYSVIP 60
MAVEQDMLIA VEPVKTHTLQ LANTDPLYPD FSTTANNICI DKTKPLWHNY FLCGFKGIQE 120
HFGLSKLPGM NCLVDGNIPP SSGLSSSSAL VCCAGLVTLT VLGLRLSKVE LAEICAKSER 180
YIGTEGGGMD QSISFLAEEG TAKLIEFSPL RATNVKLPSG AVFVIANSCM EMNKAATSHF 240
NVRVMECRLA AKVLAKHKGL QWDNVLRLEE VQSKLGISLE EMLLVTEDAL HPEPYSREEI 300
CRCLGISLER LRTQILTPNT QDELTFKLYQ RAKHVYSEAA RVLQFKQVCE DAPDNAVQLL 360
GELMNQSHRS CRDMYECSCP ELDQLVDICR KFGAKGSRLT GAGWGGCTVS LVPADMLSSF 420
LASVHEAYYQ GNTSRLAQEK HSLFATKPGG GALVFREV 458 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004335; F:galactokinase activity; IEA:InterPro.
 GO:0033858; F:N-acetylgalactosamine kinase activity; IEA:EC.
 GO:0006012; P:galactose metabolic process; IEA:InterPro. 
Interpro
 IPR000705; Galactokinase.
 IPR019741; Galactokinase_CS.
 IPR019539; GalKase_gal-bd.
 IPR013750; GHMP_kinase_C_dom.
 IPR006204; GHMP_kinase_N_dom.
 IPR006203; GHMP_knse_ATP-bd_CS.
 IPR006206; Mevalonate/galactokinase.
 IPR020568; Ribosomal_S5_D2-typ_fold.
 IPR014721; Ribosomal_S5_D2-typ_fold_subgr. 
Pfam
 PF10509; GalKase_gal_bdg
 PF08544; GHMP_kinases_C
 PF00288; GHMP_kinases_N 
SMART
  
PROSITE
 PS00106; GALACTOKINASE
 PS00627; GHMP_KINASES_ATP 
PRINTS
 PR00473; GALCTOKINASE.
 PR00959; MEVGALKINASE.