CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011175
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sister chromatid cohesion protein PDS5 
Protein Synonyms/Alias
 Precocious dissociation of sisters protein 5 
Gene Name
 PDS5 
Gene Synonyms/Alias
 YMR076C; YM9582.01C; YM9916.15C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
1097DEEEGPQKEEAPKKHacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Essential for the establishment and maintenance of sister chromatid cohesion at centromere proximal and distal regions during S phase. Also required for chromosomal condensation. 
Sequence Annotation
 REPEAT 393 429 HEAT.
 MOD_RES 1231 1231 Phosphoserine.
 MOD_RES 1233 1233 Phosphoserine.  
Keyword
 Acetylation; Cell cycle; Cell division; Complete proteome; Mitosis; Nucleus; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1277 AA 
Protein Sequence
MAKGAVTKLK FNSPIISTSD QLISTNELLD RLKALHEELA SLDQDNTDLT GLDKYRDALV 60
SRKLLKHKDV GIRAFTACCL SDILRLYAPD APYTDAQLTD IFKLVLSQFE QLGDQENGYH 120
IQQTYLITKL LEYRSIVLLA DLPSSNNLLI ELFHIFYDPN KSFPARLFNV IGGILGEVIS 180
EFDSVPLEVL RLIFNKFLTY NPNEIPEGLN VTSDCGYEVS LILCDTYSNR MSRHLTKYYS 240
EIIHEATNDD NNSRLLTVVV KLHKLVLRLW ETVPELINAV IGFIYHELSS ENELFRKEAT 300
KLIGQILTSY SDLNFVSTHS DTFKAWISKI ADISPDVRVE WTESIPQIIA TREDISKELN 360
QALAKTFIDS DPRVRRTSVM IFNKVPVTEI WKNITNKAIY TSLLHLAREK HKEVRELCIN 420
TMAKFYSNSL NEIERTYQNK EIWEIIDTIP STLYNLYYIN DLNINEQVDS VIFEYLLPFE 480
PDNDKRVHRL LTVLSHFDKK AFTSFFAFNA RQIKISFAIS KYIDFSKFLN NQESMSSSQG 540
PIVMNKYNQT LQWLASGLSD STKAIDALET IKQFNDERIF YLLNACVTND IPFLTFKNCY 600
NELVSKLQTP GLFKKYNIST GASIMPRDIA KVIQILLFRA SPIIYNVSNI SVLLNLSNNS 660
DAKQLDLKRR ILDDISKVNP TLFKDQIRTL KTIIKDLDDP DAEKNDNLSL EEALKTLYKA 720
SKTLKDQVDF DDTFFFTKLY DFAVESKPEI TKYATKLIAL SPKAEETLKK IKIRILPLDL 780
QKDKYFTSHI IVLMEIFKKF PHVLNDDSTD IISYLIKEVL LSNQVVGDSK KEIDWVEDSL 840
LSDTKYSAIG NKVFTLKLFT NKLRSIAPDV PRDELAESFT EKTMKLFFYL IASGGELISE 900
FNKEFYPTPS NYQTKLRCVA GIQVLKLARI SNLNNFIKPS DIIKLINLVE DESLPVRKTF 960
LEQLKDYVAN ELISIKFLPL VFFTAYEPDV ELKTTTKIWI NFTFGLKSFK KGTIFERALP 1020
RLIHAIAHHP DIVGGLDSEG DAYLNALTTA IDYLLFYFDS IAAQENFSLL YYLSERVKNY 1080
QDKLVEDEID EEEGPQKEEA PKKHRPYGQK MYIIGELSQM ILLNLKEKKN WQHSAYPGKL 1140
NLPSDLFKPF ATVQEAQLSF KTYIPESLTE KIQNNIKAKI GRILHTSQTQ RQRLQKRLLA 1200
HENNESQKKK KKVHHARSQA DDEEGDGDRE SDSDDDSYSP SNKNETKKGH ENIVMKKLRV 1260
RKEVDYKDDE DDDIEMT 1277 
Gene Ontology
 GO:0000794; C:condensed nuclear chromosome; IDA:SGD.
 GO:0005829; C:cytosol; IDA:SGD.
 GO:0005198; F:structural molecule activity; ISS:SGD.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0006302; P:double-strand break repair; IMP:SGD.
 GO:0007076; P:mitotic chromosome condensation; IMP:SGD.
 GO:0007064; P:mitotic sister chromatid cohesion; IMP:SGD.
 GO:0007129; P:synapsis; IMP:SGD. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold. 
Pfam
  
SMART
  
PROSITE
 PS50077; HEAT_REPEAT 
PRINTS