CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037991
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Spectrin alpha chain, non-erythrocytic 1 
Protein Synonyms/Alias
  
Gene Name
 Sptan1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
30LDRYHRFKELSTLRRacetylation[1]
39LSTLRRQKLEDSYRFacetylation[1]
58RDAEELEKWIQEKLQacetylation[1]
73VASDENYKDPTNLQGacetylation[1]
73VASDENYKDPTNLQGubiquitination[2]
150IKLLQAQKLVQYLREacetylation[1]
190HVEVLQKKFEEFQTDacetylation[1]
214EVNQFAAKLIQEQHPacetylation[1]
227HPEEELIKTKQEEVNacetylation[1]
310DLAALEDKVKALCAEacetylation[1]
441ASDEVREKLSILSEEacetylation[1]
441ASDEVREKLSILSEEubiquitination[2]
507DSVEALLKKHEDFEKacetylation[1]
514KKHEDFEKSLSAQEEacetylation[1]
586FRDSDELKSWVNEKMacetylation[1]
592LKSWVNEKMKTATDEacetylation[1]
613NLQGKVQKHQAFEAEacetylation[1]
633SRIDALEKAGQKLIDacetylation[1]
633SRIDALEKAGQKLIDubiquitination[2]
637ALEKAGQKLIDVNHYacetylation[1]
646IDVNHYAKEEVAARMacetylation[1]
661NEVISLWKKLLEATEacetylation[1]
670LLEATELKGVKLREAacetylation[1]
673ATELKGVKLREANQQacetylation[1]
718TNVQNLQKKHALLEAacetylation[1]
756HFDAENIKKKQEALVacetylation[1]
770VARYEALKEPMVARKacetylation[1]
777KEPMVARKQKLADSLacetylation[1]
779PMVARKQKLADSLRLacetylation[1]
824IGVQNLLKKHQALQAacetylation[1]
862HFAAEDVKAKLSELNacetylation[1]
871KLSELNQKWEALKAKacetylation[1]
909AESWMREKEPIVGSTubiquitination[2]
920VGSTDYGKDEDSAEAacetylation[1]
981ALYDYQEKSPREVTMubiquitination[2]
1057DNQTRITKEAGSVSLubiquitination[2]
1093MLEKSCKKFMLFREAacetylation[1]
1132QVEVLQKKFDDFQKDacetylation[1]
1141DDFQKDLKANESRLKacetylation[1]
1246HRDADETKEWIEEKNacetylation[1]
1311PESAEDLKEKCTELNacetylation[1]
1334RADQRKAKLGDSHDLacetylation[1]
1369VSSDELAKDVTGAEAacetylation[1]
1419ASPEIKEKLDILDQEacetylation[1]
1419ASPEIKEKLDILDQEubiquitination[2]
1473AFLNTEDKGDSLDSVacetylation[1]
1485DSVEALIKKHEDFDKacetylation[1]
1492KKHEDFDKAINVQEEacetylation[1]
1519IAVDHYAKGDIANRRacetylation[1]
1591NIQSKHQKHQAFEAEacetylation[1]
1698ASVNNLLKKHQLLEAacetylation[1]
1715SAHEDRLKDLNSQADacetylation[1]
1781DDEESWIKEKKLLVSacetylation[1]
1783EESWIKEKKLLVSSEacetylation[1]
1828QGVLDTGKKLSDDNTacetylation[1]
1853AQFVEHWKELKQLAAacetylation[1]
1856VEHWKELKQLAAARGacetylation[1]
1911AIQGLLKKHEAFETDacetylation[1]
1923ETDFTVHKDRVNDVCacetylation[1]
1938TNGQDLIKKNNHHEEacetylation[1]
1963GKVSDLEKAAAQRKAacetylation[1]
1971AAAQRKAKLDENSAFacetylation[1]
2000GEKENSLKTDDYGRDacetylation[1]
2052AAKHIQSKAIEARHAacetylation[1]
2052AAKHIQSKAIEARHAubiquitination[2]
2063ARHASLMKRWTQLLAacetylation[1]
2077ANSATRKKKLLEAQSacetylation[1]
2078NSATRKKKLLEAQSHacetylation[1]
2088EAQSHFRKVEDLFLTacetylation[1]
2098DLFLTFAKKASAFNSacetylation[1]
2184ETWRNLQKIIKERELacetylation[1]
2187RNLQKIIKERELELQacetylation[1]
2195ERELELQKEQRRQEEacetylation[1]
2205RRQEENDKLRQEFAQacetylation[1]
2265AMRSQLKKIEDLGAAacetylation[1]
2327GVTEEALKEFSMMFKacetylation[1]
2334KEFSMMFKHFDKDKSacetylation[1]
2338MMFKHFDKDKSGRLNacetylation[1]
2405SRETENVKSSEEIESacetylation[1]
2422RALSSEGKPYVTKEEacetylation[1]
2427EGKPYVTKEELYQNLacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113
Functional Description
  
Sequence Annotation
  
Keyword
 Calcium; Complete proteome; Reference proteome; Repeat; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2473 AA 
Protein Sequence
MDPSGVKVLE TAEDIQERRQ QVLDRYHRFK ELSTLRRQKL EDSYRFQFFQ RDAEELEKWI 60
QEKLQVASDE NYKDPTNLQG KLQKHQAFEA EVQANSGAIV KLDETGNLMI SEGHFASETI 120
RTRLMELHRQ WELLLEKMRE KGIKLLQAQK LVQYLRECED VMDWINDKEA IVTSEELGQD 180
LEHVEVLQKK FEEFQTDLAA HEERVNEVNQ FAAKLIQEQH PEEELIKTKQ EEVNAAWQRL 240
KGLALQRQGK LFGAAEVQRF NRDVDETIGW IKEKEQLMAS DDFGRDLASV QALLRKHEGL 300
ERDLAALEDK VKALCAEADR LQQSHPLSAN QIQVKREELI TNWEQIRTLA AERHARLDDS 360
YRLQRFLADF RDLTSWVTEM KALINADELA NDVAGAEALL DRHQEHKGEI DAHEDSFKSA 420
DESGQALLAA GHYASDEVRE KLSILSEERA ALLELWELRR QQYEQCMDLQ LFYRDTEQVD 480
NWMSKQEAFL LNEDLGDSLD SVEALLKKHE DFEKSLSAQE EKITALDEFA TKLIQNNHYA 540
MEDVATRRDA LLSRRNALHE RAMHRRAQLA DSFHLQQFFR DSDELKSWVN EKMKTATDEA 600
YKDPSNLQGK VQKHQAFEAE LSANQSRIDA LEKAGQKLID VNHYAKEEVA ARMNEVISLW 660
KKLLEATELK GVKLREANQQ QQFNRNVEDI ELWLYEVEGH LASDDYGKDL TNVQNLQKKH 720
ALLEADVAAH QDRIDGITIQ ARQFQDAGHF DAENIKKKQE ALVARYEALK EPMVARKQKL 780
ADSLRLQQLF RDVEDEETWI REKEPIAAST NRGKDLIGVQ NLLKKHQALQ AEIAGHEPRI 840
KAVTQKGNAM VEEGHFAAED VKAKLSELNQ KWEALKAKAS QRRQDLEDSL QAQQYFADAN 900
EAESWMREKE PIVGSTDYGK DEDSAEALLK KHEALMSDLS AYGSSIQALR EQAQSCRQQV 960
APMDDETGKE LVLALYDYQE KSPREVTMKK GDILTLLNST NKARHKAQVN DRQGFVPAAY 1020
VKKLDPAQSA SRENLLEEQG SIALRQGQID NQTRITKEAG SVSLRMKQVE ELYQSLLELG 1080
EKRKGMLEKS CKKFMLFREA NELQQWINEK EAALTSEEVG ADLEQVEVLQ KKFDDFQKDL 1140
KANESRLKDI NKVAEDLESE GLMAEEVQAV QQQEVYGMMP RDEADSKTAS PWKSARLMVH 1200
TVATFNSIKE LNERWRSLQQ LAEERSQLLG SAHEVQRFHR DADETKEWIE EKNQALNTDN 1260
YGHDLASVQA LQRKHEGFER DLAALGDKVN SLGETAQRLI QSHPESAEDL KEKCTELNQA 1320
WTSLGKRADQ RKAKLGDSHD LQRFLSDFRD LMSWINGIRG LVSSDELAKD VTGAEALLER 1380
HQEHRTEIDA RAGTFQAFEQ FGQQLLAHGH YASPEIKEKL DILDQERTDL EKAWVQRRMM 1440
LDHCLELQLF HRDCEQAENW MAAREAFLNT EDKGDSLDSV EALIKKHEDF DKAINVQEEK 1500
IAALQAFADQ LIAVDHYAKG DIANRRNEVL DRWRRLKAQM IEKRSKLGES QTLQQFSRDV 1560
DEIEAWISEK LQTASDESYK DPTNIQSKHQ KHQAFEAELH ANADRIRGVI DMGNSLIERG 1620
ACAGSEDAVK ARLAALADQW QFLVQKSAEK SQKLKEANKQ QNFNTGIKDF DFWLSEVEAL 1680
LASEDYGKDL ASVNNLLKKH QLLEADISAH EDRLKDLNSQ ADSLMTSSAF DTSQVKEKRD 1740
TINGRFQKIK SMATSRRAKL SESHRLHQFF RDMDDEESWI KEKKLLVSSE DYGRDLTGVQ 1800
NLRKKHKRLE AELAAHEPAI QGVLDTGKKL SDDNTIGQEE IQQRLAQFVE HWKELKQLAA 1860
ARGQRLEESL EYQQFVANVE EEEAWINEKM TLVASEDYGD TLAAIQGLLK KHEAFETDFT 1920
VHKDRVNDVC TNGQDLIKKN NHHEENISSK MKGLNGKVSD LEKAAAQRKA KLDENSAFLQ 1980
FNWKADVVES WIGEKENSLK TDDYGRDLSS VQTLLTKQET FDAGLQAFQQ EGIANITALK 2040
DQLLAAKHIQ SKAIEARHAS LMKRWTQLLA NSATRKKKLL EAQSHFRKVE DLFLTFAKKA 2100
SAFNSWFENA EEDLTDPVRC NSLEEIKALR EAHDAFRSSL SSAQADFNQL AELDRQIKSF 2160
RVASNPYTWF TMEALEETWR NLQKIIKERE LELQKEQRRQ EENDKLRQEF AQHANAFHQW 2220
IQETRYWSLN PESCMVEESG TLESQLEATK RKHQEIRAMR SQLKKIEDLG AAMEEALILD 2280
NKYTEHSTVG LAQQWDQLDQ LGMRMQHNLE QQIQARNTTG VTEEALKEFS MMFKHFDKDK 2340
SGRLNHQEFK SCLRSLGYDL PMVEEGEPDP EFEAILDTVD PNRDGHVSLQ EYMAFMISRE 2400
TENVKSSEEI ESAFRALSSE GKPYVTKEEL YQNLTREQAD YCVSHMKPYV DGKGRELPTA 2460
FDYVEFTRSL FVN 2473 
Gene Ontology
 GO:0005509; F:calcium ion binding; IEA:InterPro. 
Interpro
 IPR011992; EF-hand-like_dom.
 IPR014837; EF-hand_Ca_insen.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR001452; SH3_domain.
 IPR018159; Spectrin/alpha-actinin.
 IPR013315; Spectrin_alpha_SH3.
 IPR002017; Spectrin_repeat. 
Pfam
 PF13499; EF_hand_5
 PF08726; efhand_Ca_insen
 PF00018; SH3_1
 PF00435; Spectrin 
SMART
 SM00054; EFh
 SM00326; SH3
 SM00150; SPEC 
PROSITE
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2
 PS50002; SH3 
PRINTS
 PR00452; SH3DOMAIN.
 PR01887; SPECTRNALPHA.