CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027706
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Gut-enriched kruppel-like factor 
Protein Synonyms/Alias
 Kruppel-like factor 4 (Gut); Kruppel-like factor 4 (Gut), isoform CRA_a; Protein Klf4 
Gene Name
 Klf4 
Gene Synonyms/Alias
 rCG_31974 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
52REELSHMKRLPPLPGacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 482 AA 
Protein Sequence
MRQPPGESDM AVSDALLPSF STFASGPAGR EKTLRPAGAP TNRWREELSH MKRLPPLPGR 60
PYDLAATVAT DLESGGAGAA CSSNNPALPR RETEEFNDLL DLDFILSNSL SHQESVAATV 120
TTSASASSSS SPASSGPASA PSTCSFSYPI RAGGDPGVAA GNTGGGLLYS RESAPPPTAP 180
FNLADINDVS PSGGFVAELL RPELDPVYIP PQQPQPPGGG LMGKFVLKAS LSTPGSEYTS 240
PSVISVSKGS PDGSHPVVVA PYSGGPPRMC PKIKQEAVPS CTVSRSLEAH LSAGPQLSNG 300
HRPNTHDFPL GRQLPTRTTP TLSPEELLNS RDCHPGLPLP PGFHPHPGPS YPPFLPDQMQ 360
SQVPSLHYQE LMPPGSCLPE EPKPKRGRRS WPRKRTATHT CDYAGCGKTY TKSSHLKAHL 420
RTHTGEKPYH CDWDGCGWKF ARSDELTRHY RKHTGHRPFQ CQKCDRAFSR SDHLALHMKR 480
HF 482 
Gene Ontology
 GO:0000785; C:chromatin; IDA:RGD.
 GO:0000790; C:nuclear chromatin; IEA:Compara.
 GO:0005667; C:transcription factor complex; IDA:RGD.
 GO:0000987; F:core promoter proximal region sequence-specific DNA binding; IEA:Compara.
 GO:0003690; F:double-stranded DNA binding; IDA:RGD.
 GO:0035014; F:phosphatidylinositol 3-kinase regulator activity; IMP:UniProtKB.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IDA:RGD.
 GO:0001190; F:RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription; IEA:Compara.
 GO:0043565; F:sequence-specific DNA binding; IDA:RGD.
 GO:0001010; F:sequence-specific DNA binding transcription factor recruiting transcription factor activity; IEA:Compara.
 GO:0044212; F:transcription regulatory region DNA binding; IDA:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0071409; P:cellular response to cycloheximide; IEP:RGD.
 GO:0071363; P:cellular response to growth factor stimulus; IEA:Compara.
 GO:0070301; P:cellular response to hydrogen peroxide; IEP:RGD.
 GO:1901653; P:cellular response to peptide; IEP:RGD.
 GO:0009913; P:epidermal cell differentiation; IEA:Compara.
 GO:0048730; P:epidermis morphogenesis; IEA:Compara.
 GO:0045444; P:fat cell differentiation; IEA:Compara.
 GO:0090051; P:negative regulation of cell migration involved in sprouting angiogenesis; IEA:Compara.
 GO:2000342; P:negative regulation of chemokine (C-X-C motif) ligand 2 production; IEA:Compara.
 GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Compara.
 GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IMP:UniProtKB.
 GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; IEA:Compara.
 GO:0045415; P:negative regulation of interleukin-8 biosynthetic process; IEA:Compara.
 GO:0014740; P:negative regulation of muscle hyperplasia; IMP:UniProtKB.
 GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IEA:Compara.
 GO:0014067; P:negative regulation of phosphatidylinositol 3-kinase cascade; IMP:UniProtKB.
 GO:0051898; P:negative regulation of protein kinase B signaling cascade; IMP:UniProtKB.
 GO:0060761; P:negative regulation of response to cytokine stimulus; IEA:Compara.
 GO:0048662; P:negative regulation of smooth muscle cell proliferation; IMP:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IMP:UniProtKB.
 GO:0046985; P:positive regulation of hemoglobin biosynthetic process; IEA:Compara.
 GO:0031077; P:post-embryonic camera-type eye development; IEA:Compara.
 GO:0035166; P:post-embryonic hemopoiesis; IEA:Compara.
 GO:0032526; P:response to retinoic acid; IEA:Compara.
 GO:0019827; P:stem cell maintenance; IEA:Compara. 
Interpro
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
  
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS