UniProt Accession

 AP3M2_HUMAN; P53677; B2RCR0; D3DSY2 

Genbank Protein ID

 D38293; AK315228; CH471080; CH471080; CH471080; BC056398 

Genbank Nucleotide ID

 BAA07415.1; BAG37657.1; EAW63236.1; EAW63237.1; EAW63238.1; AAH56398.1 

Protein Name

 AP-3 complex subunit mu-2 

Protein Synonyms/Alias

 Adapter-related protein complex 3 mu-2 subunit; Clathrin assembly protein assembly protein complex 1 medium chain homolog 2; Clathrin coat assembly protein AP47 homolog 2; Clathrin coat-associated protein AP47 homolog 2; Golgi adaptor AP-1 47 kDa protein homolog 2; HA1 47 kDa subunit homolog 2; Mu3B-adaptin; P47B 

Gene Name

 AP3M2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
135	NILKELIKPPTILRT	ubiquitination	[1]
398	RLDMYGEKYKPFKGI	ubiquitination	[1, 2]
400	DMYGEKYKPFKGIKY	ubiquitination	[2]
413	KYMTKAGKFQVRT**	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. 

Sequence Annotation

 DOMAIN 176 417 MHD.  

Keyword

 Complete proteome; Golgi apparatus; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 418 AA 

Protein Sequence

Gene Ontology

 GO:0030119; C:AP-type membrane coat adaptor complex; TAS:ProtInc.
 GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0008089; P:anterograde axon cargo transport; ISS:UniProtKB.
 GO:0048490; P:anterograde synaptic vesicle transport; ISS:UniProtKB.
 GO:0006886; P:intracellular protein transport; IEA:InterPro. 

Interpro

 IPR022775; AP_mu_sigma_su.
 IPR001392; Clathrin_mu.
 IPR008968; Clathrin_mu_C.
 IPR018240; Clathrin_mu_CS.
 IPR011012; Longin-like_dom. 

Pfam

 PF00928; Adap_comp_sub
 PF01217; Clat_adaptor_s 

SMART

  

PROSITE

 PS00990; CLAT_ADAPTOR_M_1
 PS00991; CLAT_ADAPTOR_M_2
 PS51072; MHD 

PRINTS

 PR00314; CLATHRINADPT.