UniProt Accession

 CDC6_HUMAN; Q99741; Q8TB30 

Genbank Protein ID

 U77949; AF022109; AY150310; BC025232 

Genbank Nucleotide ID

 AAB38317.1; AAC52071.1; AAN10296.1; AAH25232.1 

Protein Name

 Cell division control protein 6 homolog 

Protein Synonyms/Alias

 CDC6-related protein; Cdc18-related protein; HsCdc18; p62(cdc6); HsCDC6 

Gene Name

 CDC6 

Gene Synonyms/Alias

 CDC18L 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
25	KLSRALNKAKNSSDA	ubiquitination	[1]
27	SRALNKAKNSSDAKL	ubiquitination	[1]
33	AKNSSDAKLEPTNVQ	ubiquitination	[2]
92	PPHSHTLKGRRLVFD	acetylation	[3]
105	FDNQLTIKSPSKREL	acetylation	[3]
109	LTIKSPSKRELAKVH	acetylation	[3]
151	SACVRLFKQEGTCYQ	ubiquitination	[2]
208	SGAPGTGKTACLSRI	ubiquitination	[2]
220	SRILQDLKKELKGFK	ubiquitination	[2]
221	RILQDLKKELKGFKT	ubiquitination	[2]
261	EVSRPAGKDMMRKLE	ubiquitination	[4]
406	EIVESDVKSQTILKP	ubiquitination	[2]
412	VKSQTILKPLSECKS	ubiquitination	[2]
418	LKPLSECKSPSEPLI	ubiquitination	[2]
427	PSEPLIPKRVGLIHI	ubiquitination	[1]
478	LIRQLKIKEVTLGKL	ubiquitination	[2]
491	KLYEAYSKVCRKQQV	ubiquitination	[2, 4]
495	AYSKVCRKQQVAAVD	ubiquitination	[2]
531	NKETRLTKVFFKIEE	ubiquitination	[2]
539	VFFKIEEKEIEHALK	ubiquitination	[2]
546	KEIEHALKDKALIGN	ubiquitination	[2]
548	IEHALKDKALIGNIL	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Acetylation by GCN5 regulates CDC6 phosphorylation in the S phase of the cell cycle.
 Paolinelli R, Mendoza-Maldonado R, Cereseto A, Giacca M.
 Nat Struct Mol Biol. 2009 Apr;16(4):412-20. [PMID: 19343071]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. 

Sequence Annotation

 NP_BIND 202 209 ATP (Potential).
 MOD_RES 45 45 Phosphoserine.
 MOD_RES 54 54 Phosphoserine.
 MOD_RES 127 127 Phosphoserine.  

Keyword

 3D-structure; ATP-binding; Cell cycle; Cell division; Complete proteome; Cytoplasm; Disease mutation; DNA replication; Dwarfism; Mitosis; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 560 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0051233; C:spindle midzone; IDA:BHF-UCL.
 GO:0000922; C:spindle pole; IDA:BHF-UCL.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.
 GO:0000166; F:nucleotide binding; TAS:ProtInc.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0006260; P:DNA replication; TAS:Reactome.
 GO:0000076; P:DNA replication checkpoint; TAS:ProtInc.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc.
 GO:0008156; P:negative regulation of DNA replication; TAS:ProtInc.
 GO:0051984; P:positive regulation of chromosome segregation; IDA:BHF-UCL.
 GO:0032467; P:positive regulation of cytokinesis; IMP:BHF-UCL.
 GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; TAS:ProtInc.
 GO:0030071; P:regulation of mitotic metaphase/anaphase transition; IMP:BHF-UCL.
 GO:0000083; P:regulation of transcription involved in G1/S phase of mitotic cell cycle; TAS:Reactome.
 GO:0007089; P:traversing start control point of mitotic cell cycle; TAS:ProtInc. 

Interpro

 IPR003593; AAA+_ATPase.
 IPR015163; Cdc6_C_dom.
 IPR016314; Cell_div_Cdc6/18.
 IPR027417; P-loop_NTPase.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF09079; Cdc6_C 

SMART

 SM00382; AAA
 SM01074; Cdc6_C 

PROSITE

  

PRINTS