CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016264
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Methyltransferase-like protein 16 
Protein Synonyms/Alias
 Methyltransferase 10 domain-containing protein 
Gene Name
 METTL16 
Gene Synonyms/Alias
 METT10D 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
47GRVSLNFKDPEAVRAubiquitination[1]
144MCFNYAKKNVEQNNLubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Probable methyltransferase (By similarity). 
Sequence Annotation
 BINDING 82 82 S-adenosyl-L-methionine.
 BINDING 110 110 S-adenosyl-L-methionine; via carbonyl
 BINDING 133 133 S-adenosyl-L-methionine.
 BINDING 164 164 S-adenosyl-L-methionine.
 BINDING 184 184 S-adenosyl-L-methionine.
 MOD_RES 329 329 Phosphoserine.
 MOD_RES 450 450 Phosphoserine (By similarity).  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Methyltransferase; Phosphoprotein; Polymorphism; Reference proteome; S-adenosyl-L-methionine; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 562 AA 
Protein Sequence
MALSKSMHAR NRYKDKPPDF AYLASKYPDF KQHVQINLNG RVSLNFKDPE AVRALTCTLL 60
REDFGLSIDI PLERLIPTVP LRLNYIHWVE DLIGHQDSDK STLRRGIDIG TGASCIYPLL 120
GATLNGWYFL ATEVDDMCFN YAKKNVEQNN LSDLIKVVKV PQKTLLMDAL KEESEIIYDF 180
CMCNPPFFAN QLEAKGVNSR NPRRPPPSSV NTGGITEIMA EGGELEFVKR IIHDSLQLKK 240
RLRWYSCMLG KKCSLAPLKE ELRIQGVPKV TYTEFCQGRT MRWALAWSFY DDVTVPSPPS 300
KRRKLEKPRK PITFVVLASV MKELSLKASP LRSETAEGIV VVTTWIEKIL TDLKVQHKRV 360
PCGKEEVSLF LTAIENSWIH LRRKKRERVR QLREVPRAPE DVIQALEEKK PTPKESGNSQ 420
ELARGPQERT PCGPALREGE AAAVEGPCPS QESLSQEENP EPTEDERSEE KGGVEVLESC 480
QGSSNGAQDQ EASEQFGSPV AERGKRLPGV AGQYLFKCLI NVKKEVDDAL VEMHWVEGQN 540
RDLMNQLCTY IRNQIFRLVA VN 562 
Gene Ontology
 GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW. 
Interpro
 IPR010286; rRNA_lsu_MeTfrase_F-like.
 IPR017182; S-AdoMet-dep_MeTrfase_Mett10D. 
Pfam
 PF05971; Methyltransf_10 
SMART
  
PROSITE
  
PRINTS