UniProt Accession

 CISD2_HUMAN; Q8N5K1; Q7Z3D5 

Genbank Protein ID

 AK292134; BX537971; CH471057; BC032300 

Genbank Nucleotide ID

 BAF84823.1; CAD97935.1; EAX06148.1; AAH32300.1 

Protein Name

 CDGSH iron-sulfur domain-containing protein 2 

Protein Synonyms/Alias

 Endoplasmic reticulum intermembrane small protein; MitoNEET-related 1 protein; Miner1; Nutrient-deprivation autophagy factor-1; NAF-1 

Gene Name

 CISD2 

Gene Synonyms/Alias

 CDGSH2; ERIS; ZCD2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
19	VQLPAYLKRLPVPES	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy. 

Sequence Annotation

 METAL 99 99 Iron-sulfur (2Fe-2S).
 METAL 101 101 Iron-sulfur (2Fe-2S).
 METAL 110 110 Iron-sulfur (2Fe-2S).
 METAL 114 114 Iron-sulfur (2Fe-2S); via pros nitrogen.  

Keyword

 2Fe-2S; 3D-structure; Autophagy; Complete proteome; Deafness; Diabetes mellitus; Direct protein sequencing; Endoplasmic reticulum; Iron; Iron-sulfur; Membrane; Metal-binding; Mitochondrion; Mitochondrion outer membrane; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 135 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005741; C:mitochondrial outer membrane; ISS:UniProtKB.
 GO:0043234; C:protein complex; IDA:LIFEdb.
 GO:0051537; F:2 iron, 2 sulfur cluster binding; IDA:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
 GO:0000422; P:mitochondrion degradation; IEA:Compara.
 GO:0010259; P:multicellular organismal aging; ISS:UniProtKB.
 GO:0010506; P:regulation of autophagy; IMP:UniProtKB. 

Interpro

 IPR018967; FeS-contain_CDGSH-typ.
 IPR006622; FeS-contain_CDGSH-typ_subfam.
 IPR019610; FeS-contain_mitoNEET_N. 

Pfam

 PF10660; MitoNEET_N
 PF09360; zf-CDGSH 

SMART

 SM00704; ZnF_CDGSH 

PROSITE

  

PRINTS