CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027411
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 AT28346p 
Protein Synonyms/Alias
  
Gene Name
 p53 
Gene Synonyms/Alias
 CG33336 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
29CTAMSLHKSASFSLTsumoylation[1]
305PLTANNAKMRESLLRsumoylation[1]
Reference
 [1] Modification of Drosophila p53 by SUMO modulates its transactivation and pro-apoptotic functions.
 Mauri F, McNamee LM, Lunardi A, Chiacchiera F, Del Sal G, Brodsky MH, Collavin L.
 J Biol Chem. 2008 Jul 25;283(30):20848-56. [PMID: 18492669
Functional Description
  
Sequence Annotation
  
Keyword
 3D-structure. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 519 AA 
Protein Sequence
WSTEDSCGHK SQLLNKIYLF ECTAMSLHKS ASFSLTFNQN TSIVSRSNSR TIFEAFKEFL 60
DFWDIGNEVS AESAVRVSSN GAFNLPQSFG NESNEYAHLA TPVDPAYGGN NTNNMMQFTN 120
NLEILANNNS DGNNKINACN KFVCHKGTDS EDDSTEVDIK EDIPKTVEVS GSELTTEPMA 180
FLQGLNSGNL MQFSQQSVLR EMMLQDIQIQ ANTLPKLENH NIGGYCFSMV LDEPPKSLWM 240
YSIPLNKLYI RMNKAFNVDV QFKSKMPIQP LNLRVFLCFS NDVSAPVVRC QNHLSVEPLT 300
ANNAKMRESL LRSENPNSVY CGNAQGKGIS ERFSVVVPLN MSRSVTRSGL TRQTLAFKFV 360
CQNSCIGRKE TSLVFCLEKA CGDIVGQHVI HVKICTCPKR DRIQDERQLN SKKRKSVPEA 420
AEEDEPSKVR RCIAIKTEDT ESNDSRDCDD SAAEWNVSRT PDGDYRLAIT CPNKEWLLQS 480
IEGMIKEAAA EVLRNPNQEN LRRHANKLLS LKKRAYELP 519 
Gene Ontology
 GO:0000785; C:chromatin; IBA:RefGenome.
 GO:0005829; C:cytosol; IBA:RefGenome.
 GO:0005667; C:transcription factor complex; IBA:RefGenome.
 GO:0003682; F:chromatin binding; IBA:RefGenome.
 GO:0003684; F:damaged DNA binding; IBA:RefGenome.
 GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.
 GO:0002039; F:p53 binding; IBA:RefGenome.
 GO:0043565; F:sequence-specific DNA binding; IBA:RefGenome.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IBA:RefGenome.
 GO:0044212; F:transcription regulatory region DNA binding; IEA:InterPro.
 GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:FlyBase.
 GO:0034644; P:cellular response to UV; IBA:RefGenome.
 GO:0008340; P:determination of adult lifespan; IMP:FlyBase.
 GO:0006978; P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; IBA:RefGenome.
 GO:0035234; P:germ cell programmed cell death; IMP:FlyBase.
 GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IMP:FlyBase.
 GO:0031571; P:mitotic G1 DNA damage checkpoint; IBA:RefGenome.
 GO:0046533; P:negative regulation of photoreceptor cell differentiation; IMP:FlyBase.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IBA:RefGenome.
 GO:0014016; P:neuroblast differentiation; IMP:FlyBase.
 GO:0007405; P:neuroblast proliferation; IMP:FlyBase.
 GO:0048477; P:oogenesis; IGI:FlyBase.
 GO:0045787; P:positive regulation of cell cycle; IGI:FlyBase.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:FlyBase.
 GO:0007131; P:reciprocal meiotic recombination; IMP:FlyBase.
 GO:0042127; P:regulation of cell proliferation; IMP:FlyBase.
 GO:0043523; P:regulation of neuron apoptotic process; IBA:RefGenome.
 GO:0046620; P:regulation of organ growth; IMP:FlyBase.
 GO:0010332; P:response to gamma radiation; IBA:RefGenome.
 GO:0010165; P:response to X-ray; IBA:RefGenome.
 GO:0042246; P:tissue regeneration; IMP:FlyBase. 
Interpro
 IPR008967; p53-like_TF_DNA-bd.
 IPR012346; p53/RUNT-type_TF_DNA-bd.
 IPR024631; p53_C_Drosophila.
 IPR011615; p53_DNA-bd.
 IPR002117; p53_tumour_suppressor. 
Pfam
 PF00870; P53
 PF11619; P53_C 
SMART
  
PROSITE
  
PRINTS