| Tag | Content |
|---|
| CPLM ID | CPLM-011903 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Rho guanine nucleotide exchange factor 5 |
Protein Synonyms/Alias | Ephexin-3; Guanine nucleotide regulatory protein TIM; Oncogene TIM; Transforming immortalized mammary oncogene; p60 TIM |
Gene Name | ARHGEF5 |
Gene Synonyms/Alias | TIM |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 29 | YSDVVLNKEIQSQQR | ubiquitination | [1] | | 251 | LLLQNILKRTQPGSS | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | |
Sequence Annotation | DOMAIN 1174 1358 DH.
DOMAIN 1390 1502 PH.
DOMAIN 1513 1569 SH3.
MOD_RES 184 184 Phosphoserine.
MOD_RES 445 445 Phosphoserine.
MOD_RES 450 450 Phosphoserine.
MOD_RES 1126 1126 Phosphoserine. |
Keyword | Alternative splicing; Complete proteome; Guanine-nucleotide releasing factor; Phosphoprotein; Proto-oncogene; Reference proteome; SH3 domain. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1597 AA |
Protein Sequence | MGGFSRRCSK LINSSQLLYQ EYSDVVLNKE IQSQQRLESL SETPGPSSPR QPRKALVSSE 60
SYLQRLSMAS SGSLWQEIPV VRNSTVLLSM THEDQKLQEV KFELIVSEAS YLRSLNIAVD 120
HFQLSTSLRA TLSNQEHQWL FSRLQDVRDV SATFLSDLEE NFENNIFSFQ VCDVVLNHAP 180
DFRRVYLPYV TNQTYQERTF QSLMNSNSNF REVLEKLESD PVCQRLSLKS FLILPFQRIT 240
RLKLLLQNIL KRTQPGSSEE AEATKAHHAL EQLIRDCNNN VQSMRRTEEL IYLSQKIEFE 300
CKIFPLISQS RWLVKSGELT ALEFSASPGL RRKLNTRPVH LHLFNDCLLL SRPREGSRFL 360
VFDHAPFSSI RGEKCEMKLH GPHKNLFRLF LRQNTQGAQA EFLFRTETQS EKLRWISALA 420
MPREELDLLE CYNSPQVQCL RAYKPRENDE LALEKADVVM VTQQSSDGWL EGVRLSDGER 480
GWFPVQQVEF ISNPEVRAQN LKEAHRVKTA KLQLVEQQA 519 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:HPA. GO:0005886; C:plasma membrane; IDA:HPA. GO:0005525; F:GTP binding; TAS:ProtInc. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. GO:0030036; P:actin cytoskeleton organization; IEA:Compara. GO:0035556; P:intracellular signal transduction; IEA:InterPro. GO:0002408; P:myeloid dendritic cell chemotaxis; IEA:Compara. GO:0071803; P:positive regulation of podosome assembly; IEA:Compara. GO:0032321; P:positive regulation of Rho GTPase activity; IEA:Compara. GO:0032319; P:regulation of Rho GTPase activity; IDA:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |