UniProt Accession

 RAB8A_MOUSE; P55258; Q8VCF6 

Genbank Protein ID

 S53270; AK076048; AK079306; AK080740; BC019990 

Genbank Nucleotide ID

 AAB19682.1; BAC36146.1; BAC37603.1; BAC38003.1; AAH19990.1 

Protein Name

 Ras-related protein Rab-8A 

Protein Synonyms/Alias

 Oncogene c-mel 

Gene Name

 Rab8a 

Gene Synonyms/Alias

 Mel; Rab8 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
116	HASADVEKMILGNKC	ubiquitination	[1]
138	VSKERGEKLALDYGI	ubiquitination	[1]
153	KFMETSAKANINVEN	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 May be involved in vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization. Plays an important role in ciliogenesis (By similarity). 

Sequence Annotation

 NP_BIND 15 22 GTP (By similarity).
 NP_BIND 63 67 GTP (By similarity).
 NP_BIND 121 124 GTP (By similarity).
 MOTIF 37 45 Effector region (By similarity).
 MOD_RES 181 181 Phosphoserine (By similarity).
 MOD_RES 185 185 Phosphoserine (By similarity).
 MOD_RES 204 204 Cysteine methyl ester (Potential).
 LIPID 204 204 S-geranylgeranyl cysteine (By  

Keyword

 3D-structure; Cell membrane; Cell projection; Cilium biogenesis/degradation; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Direct protein sequencing; Golgi apparatus; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Phosphoprotein; Prenylation; Protein transport; Proto-oncogene; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 207 AA 

Protein Sequence

Gene Ontology

 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0005932; C:microtubule basal body; IDA:MGI.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0031513; C:nonmotile primary cilium; IDA:MGI.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0045335; C:phagocytic vesicle; ISS:UniProtKB.
 GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0014069; C:postsynaptic density; IEA:Compara.
 GO:0055037; C:recycling endosome; IDA:MGI.
 GO:0019003; F:GDP binding; ISS:UniProtKB.
 GO:0005525; F:GTP binding; ISS:UniProtKB.
 GO:0017137; F:Rab GTPase binding; ISS:UniProtKB.
 GO:0007409; P:axonogenesis; ISS:UniProtKB.
 GO:0042384; P:cilium assembly; ISS:UniProtKB.
 GO:0048210; P:Golgi vesicle fusion to target membrane; IEA:Compara.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IEA:Compara.
 GO:0051223; P:regulation of protein transport; IEA:Compara.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
 GO:0006904; P:vesicle docking involved in exocytosis; IEA:Compara. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 

Pfam

 PF00071; Ras 

SMART

 SM00175; RAB 

PROSITE

 PS51419; RAB 

PRINTS

 PR00449; RASTRNSFRMNG.