| Tag | Content |
|---|
| CPLM ID | CPLM-002424 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Pyruvate dehydrogenase [ubiquinone] |
Protein Synonyms/Alias | Pyruvate oxidase; POX; Alpha-peptide |
Gene Name | poxB |
Gene Synonyms/Alias | b0871; JW0855 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 11 | TVAAYIAKTLESAGV | acetylation | [1] | | 166 | LPGDVALKPAPEGAT | acetylation | [1] | | 217 | SGCAGAHKELVEFAG | acetylation | [1] | | 225 | ELVEFAGKIKAPIVH | acetylation | [1] | | 287 | AFYPTDAKIIQIDIN | acetylation | [1] | | 313 | MALVGDIKSTLRALL | acetylation | [1] | | 334 | ADRKFLDKALEDYRD | acetylation | [1] | | 344 | EDYRDARKGLDDLAK | acetylation | [1] | | 351 | KGLDDLAKPSEKAIH | acetylation | [1] | | 355 | DLAKPSEKAIHPQYL | acetylation | [1] | | 503 | ITGIRVEKASEVDEA | acetylation | [1] | | 539 | LAIPPQIKLEQAKGF | acetylation | [1] | | 544 | QIKLEQAKGFSLYML | acetylation | [1] | | 567 | DEVIELAKTNWLR** | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | |
Sequence Annotation | |
Keyword | 3D-structure; Cell membrane; Complete proteome; Direct protein sequencing; FAD; Flavoprotein; Lipid-binding; Magnesium; Membrane; Oxidoreductase; Reference proteome; Thiamine pyrophosphate. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 572 AA |
Protein Sequence | MKQTVAAYIA KTLESAGVKR IWGVTGDSLN GLSDSLNRMG TIEWMSTRHE EVAAFAAGAE 60
AQLSGELAVC AGSCGPGNLH LINGLFDCHR NHVPVLAIAA HIPSSEIGSG YFQETHPQEL 120
FRECSHYCEL VSSPEQIPQV LAIAMRKAVL NRGVSVVVLP GDVALKPAPE GATMHWYHAP 180
QPVVTPEEEE LRKLAQLLRY SSNIALMCGS GCAGAHKELV EFAGKIKAPI VHALRGKEHV 240
EYDNPYDVGM TGLIGFSSGF HTMMNADTLV LLGTQFPYRA FYPTDAKIIQ IDINPASIGA 300
HSKVDMALVG DIKSTLRALL PLVEEKADRK FLDKALEDYR DARKGLDDLA KPSEKAIHPQ 360
YLAQQISHFA ADDAIFTCDV GTPTVWAARY LKMNGKRRLL GSFNHGSMAN AMPQALGAQA 420
TEPERQVVAM CGDGGFSMLM GDFLSVVQMK LPVKIVVFNN SVLGFVAMEM KAGGYLTDGT 480
ELHDTNFARI AEACGITGIR VEKASEVDEA LQRAFSIDGP VLVDVVVAKE ELAIPPQIKL 540
EQAKGFSLYM LRAIISGRGD EVIELAKTNW LR 572 |
Gene Ontology | GO:0005829; C:cytosol; IDA:UniProtKB. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0008289; F:lipid binding; IEA:UniProtKB-KW. GO:0000287; F:magnesium ion binding; IEA:InterPro. GO:0052737; F:pyruvate dehydrogenase (quinone) activity; IEA:EC. GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |