UniProt Accession

 PCY2_HUMAN; Q99447; B7Z7A5; F5H8B1; Q6IBM3; Q96G08 

Genbank Protein ID

 D84307; CR456779; AK301723; AC145207; CH471099; BC000351; BC010075 

Genbank Nucleotide ID

 BAA12311.1; CAG33060.1; BAH13541.1; EAW89705.1; AAH00351.1; AAH10075.1 

Protein Name

 Ethanolamine-phosphate cytidylyltransferase 

Protein Synonyms/Alias

 CTP:phosphoethanolamine cytidylyltransferase; Phosphorylethanolamine transferase 

Gene Name

 PCYT2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
66	DEEIAKHKGPPVFTQ	ubiquitination	[1]
78	FTQEERYKMVQAIKW	ubiquitination	[2]
130	RDTYEEVKQAGRYRE	ubiquitination	[1, 2]
179	EYADSFGKCPGGRNP	ubiquitination	[2]
366	RNQKKEAKELAFLEA	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Plays an important role in the biosynthesis of the phospholipid phosphatidylethanolamine. Catalyzes the formation of CDP-ethanolamine. 

Sequence Annotation

 NP_BIND 221 222 CTP.
 NP_BIND 229 232 CTP.
 NP_BIND 307 310 CTP.
 NP_BIND 336 340 CTP.
 BINDING 259 259 CTP.  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Lipid biosynthesis; Lipid metabolism; Nucleotidyltransferase; Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome; Repeat; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 389 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0004306; F:ethanolamine-phosphate cytidylyltransferase activity; TAS:UniProtKB.
 GO:0006646; P:phosphatidylethanolamine biosynthetic process; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR004821; Cyt_trans-like.
 IPR014729; Rossmann-like_a/b/a_fold. 

Pfam

 PF01467; CTP_transf_2 

SMART

  

PROSITE

  

PRINTS