| Tag | Content |
|---|
| CPLM ID | CPLM-025700 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cobyric acid synthase |
Protein Synonyms/Alias | |
Gene Name | cobQ |
Gene Synonyms/Alias | TTHB066 |
Created Date | July 27, 2013 |
Organism | Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) |
NCBI Taxa ID | 300852 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 479 | RDEEMAEKIRRHQEE | acetylation | [1] |
|
Reference | [1] Acetylome with structural mapping reveals the significance of lysine acetylation in Thermus thermophilus. Okanishi H, Kim K, Masui R, Kuramitsu S. J Proteome Res. 2013 Aug 1;. [ PMID: 23901841] |
Functional Description | Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity). |
Sequence Annotation | DOMAIN 202 375 GATase cobBQ-type (By similarity).
ACT_SITE 279 279 Nucleophile (By similarity).
ACT_SITE 367 367 By similarity. |
Keyword | Cobalamin biosynthesis; Complete proteome; Glutamine amidotransferase; Kinase; Plasmid; Reference proteome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 629 AA |
Protein Sequence | MANHARVVRG GEMASAQWLQ ALAAGVEPEV RMNPVLVKPF GERGAQVVVW GKVDPFLSGL 60
PWKERRPHLE APVREALEGL LAEYDLLVLE GAGSPVERNL WPDLPNLRVA EWADAKALLV 120
ADVDQGGALG ALYGTWALLG EHRKRLIGFA FNKFRGDLEL LKPAYALLRD WTGLPVLGTL 180
PLLPLALPEE DGFRYRQPAG NGPKVALLRY PHAANLDEFW PLSELAQVVY AHSPEEAEGA 240
WLLILPGSRL PARDLPWLRA FLPLIQRHLE AGKPVLAVCG GAEMLSEALL DEEGVEERGH 300
FPGLGLLPYR VRMAREKTVE RRRVRLRGLS GYWGRLEGLE VEGYEIHHGQ GLPLFHQEGS 360
LLATWLHGLL ENPGVQKALF GREARGLEEG LEALADALER HLDLRALHRA LGLTGRAFPA 420
SPTEAKAPVG CPDPPPPPGL VLLLGGAKSG KSRFAQRLAG PFATLVATAE ARDEEMAEKI 480
RRHQEERPPT WETLEAPLDL VGALKRARHP TVVVDCLTLW VANLMERGLD PLLEARRFLS 540
AVEESGKRVI AVSNEVGMGI VPQNPLARRY RDLLGQVNAL LAEAAQEAYL LVAGRALPLG 600
GGKVPAQEAK RPGSHGGEPG PGRSRDPGP 629 |
Gene Ontology | GO:0043752; F:adenosylcobinamide kinase activity; IEA:InterPro. GO:0015420; F:cobalamin-transporting ATPase activity; IEA:HAMAP. GO:0000166; F:nucleotide binding; IEA:InterPro. GO:0009236; P:cobalamin biosynthetic process; IEA:HAMAP. GO:0051188; P:cofactor biosynthetic process; IEA:InterPro. GO:0006541; P:glutamine metabolic process; IEA:HAMAP. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |