UniProt Accession

 CERU_HUMAN; P00450; Q14063; Q2PP18; Q9UKS4 

Genbank Protein ID

 M13699; DQ314867; D45045; D00025; X04135; X04136; X04137; X04138; AF132978; M13536; J05506 

Genbank Nucleotide ID

 AAA51976.1; ABC40726.1; BAA08085.1; BAA00019.1; CAA27752.1; CAA27753.1; CAA27754.1; CAA27755.1; AAF02483.1; AAA51975.1 

Protein Name

 Ceruloplasmin 

Protein Synonyms/Alias

 Ferroxidase 

Gene Name

 CP 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
468	IRVTFHNKGAYPLSI	glycation	[1]

Reference

 [1] Proteomic profiling of nonenzymatically glycated proteins in human plasma and erythrocyte membranes.
 Zhang Q, Tang N, Schepmoes AA, Phillips LS, Smith RD, Metz TO.
 J Proteome Res. 2008 May;7(5):2025-32. [PMID: 18396901] 

Functional Description

 Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity). 

Sequence Annotation

 DOMAIN 20 357 F5/8 type A 1.
 DOMAIN 20 200 Plastocyanin-like 1.
 DOMAIN 209 357 Plastocyanin-like 2.
 DOMAIN 370 718 F5/8 type A 2.
 DOMAIN 370 560 Plastocyanin-like 3.
 DOMAIN 570 718 Plastocyanin-like 4.
 DOMAIN 730 1061 F5/8 type A 3.
 DOMAIN 730 900 Plastocyanin-like 5.
 DOMAIN 908 1061 Plastocyanin-like 6.
 METAL 120 120 Copper 1; type 2.
 METAL 122 122 Copper 2; type 3.
 METAL 180 180 Copper 2; type 3.
 METAL 182 182 Copper 3; type 3.
 METAL 295 295 Copper 4; type 1.
 METAL 338 338 Copper 4; type 1.
 METAL 343 343 Copper 4; type 1.
 METAL 656 656 Copper 5; type 1.
 METAL 699 699 Copper 5; type 1.
 METAL 704 704 Copper 5; type 1.
 METAL 709 709 Copper 5; type 1.
 METAL 994 994 Copper 6; type 1.
 METAL 997 997 Copper 1; type 2.
 METAL 999 999 Copper 3; type 3.
 METAL 1039 1039 Copper 3; type 3.
 METAL 1040 1040 Copper 6; type 1.
 METAL 1041 1041 Copper 2; type 3.
 METAL 1045 1045 Copper 6; type 1.
 METAL 1050 1050 Copper 6; type 1.
 CARBOHYD 138 138 N-linked (GlcNAc...) (complex).
 CARBOHYD 358 358 N-linked (GlcNAc...) (complex).
 CARBOHYD 397 397 N-linked (GlcNAc...) (complex).
 CARBOHYD 588 588 N-linked (GlcNAc...).
 CARBOHYD 762 762 N-linked (GlcNAc...).
 CARBOHYD 926 926 N-linked (GlcNAc...).
 DISULFID 174 200 Probable.
 DISULFID 276 357 Probable.
 DISULFID 534 560 Probable.
 DISULFID 637 718 Probable.
 DISULFID 874 900 Probable.  

Keyword

 3D-structure; Complete proteome; Copper; Copper transport; Direct protein sequencing; Disulfide bond; Glycoprotein; Ion transport; Metal-binding; Oxidoreductase; Polymorphism; Reference proteome; Repeat; Secreted; Signal; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1065 AA 

Protein Sequence

Gene Ontology

 GO:0005615; C:extracellular space; IDA:BHF-UCL.
 GO:0005507; F:copper ion binding; IEA:Compara.
 GO:0004322; F:ferroxidase activity; TAS:ProtInc.
 GO:0006879; P:cellular iron ion homeostasis; TAS:Reactome.
 GO:0006825; P:copper ion transport; IEA:UniProtKB-KW.
 GO:0055085; P:transmembrane transport; TAS:Reactome. 

Interpro

 IPR027150; CP.
 IPR001117; Cu-oxidase.
 IPR011706; Cu-oxidase_2.
 IPR011707; Cu-oxidase_3.
 IPR002355; Cu_oxidase_Cu_BS.
 IPR008972; Cupredoxin. 

Pfam

 PF00394; Cu-oxidase
 PF07731; Cu-oxidase_2
 PF07732; Cu-oxidase_3 

SMART

  

PROSITE

 PS00079; MULTICOPPER_OXIDASE1
 PS00080; MULTICOPPER_OXIDASE2 

PRINTS