CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040024
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Thioredoxin reductase 1, cytoplasmic 
Protein Synonyms/Alias
  
Gene Name
 TXNRD1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
30NVGCIPKKLMHQAALubiquitination[1]
217IRQFVPIKVEQIEAGubiquitination[1]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; FAD; Flavoprotein; Oxidoreductase; Redox-active center; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 459 AA 
Protein Sequence
MVLDFVTPTP LGTRWGLGGT CVNVGCIPKK LMHQAALLGQ ALQDSRNYGW KVEETVKHDW 60
DRMIEAVQNH IGSLNWGYRV ALREKKVVYE NAYGQFIGPH RIKATNNKGK EKIYSAERFL 120
IATGERPRYL GIPGDKEYCI SSDDLFSLPY CPGKTLVVGA SYVALECAGF LAGIGLDVTV 180
MVRSILLRGF DQDMANKIGE HMEEHGIKFI RQFVPIKVEQ IEAGTPGRLR VVAQSTNSEE 240
IIEGEYNTVM LAIGRDACTR KIGLETVGVK INEKTGKIPV TDEEQTNVPY IYAIGDILED 300
KVELTPVAIQ AGRLLAQRLY AGSTVKCDYE NVPTTVFTPL EYGACGLSEE KAVEKFGEEN 360
IEVYHSYFWP LEWTIPSRDN NKCYAKIICN TKDNERVVGF HVLGPNAGEV TQGFAAALKC 420
GLTKKQLDST IGIHPVCAEV FTTLSVTKRS GASILQAGC 459 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
 GO:0045340; F:mercury ion binding; IEA:Compara.
 GO:0016174; F:NAD(P)H oxidase activity; IEA:Compara.
 GO:0050661; F:NADP binding; IEA:InterPro.
 GO:0033797; F:selenate reductase activity; IEA:Compara.
 GO:0004791; F:thioredoxin-disulfide reductase activity; IEA:Compara.
 GO:0042537; P:benzene-containing compound metabolic process; IEA:Compara.
 GO:0008283; P:cell proliferation; IEA:Compara.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro.
 GO:0071280; P:cellular response to copper ion; IEA:Compara.
 GO:0071455; P:cellular response to hyperoxia; IEA:Compara.
 GO:0006749; P:glutathione metabolic process; IEA:Compara.
 GO:0070276; P:halogen metabolic process; IEA:Compara.
 GO:0042744; P:hydrogen peroxide catabolic process; IEA:Compara.
 GO:0001707; P:mesoderm formation; IEA:Compara.
 GO:0042191; P:methylmercury metabolic process; IEA:Compara.
 GO:0070995; P:NADPH oxidation; IEA:Compara.
 GO:0001890; P:placenta development; IEA:Compara.
 GO:0010942; P:positive regulation of cell death; IEA:Compara.
 GO:0051262; P:protein tetramerization; IEA:Compara.
 GO:0048678; P:response to axon injury; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0010269; P:response to selenium ion; IEA:Compara.
 GO:0016259; P:selenocysteine metabolic process; IEA:Compara. 
Interpro
 IPR016156; FAD/NAD-linked_Rdtase_dimer.
 IPR013027; FAD_pyr_nucl-diS_OxRdtase.
 IPR004099; Pyr_nucl-diS_OxRdtase_dimer.
 IPR023753; Pyr_nucl-diS_OxRdtase_FAD/NAD.
 IPR012999; Pyr_OxRdtase_I_AS.
 IPR001327; Pyr_OxRdtase_NAD-bd_dom.
 IPR006338; Thioredoxin/glutathione_Rdtase. 
Pfam
 PF00070; Pyr_redox
 PF07992; Pyr_redox_2
 PF02852; Pyr_redox_dim 
SMART
  
PROSITE
 PS00076; PYRIDINE_REDOX_1 
PRINTS
 PR00368; FADPNR.