CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035696
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Whsc1 
Protein Synonyms/Alias
  
Gene Name
 Whsc1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
1321ANNTKTEKPFLDSLKacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Methyltransferase; Nucleus; Reference proteome; Transferase; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1346 AA 
Protein Sequence
MKQAPEILGS ANGKTQNCEV NHECSVFLSK AQLSNSLQEG VMQKFNGHDA LPFLPAEKLK 60
DLTSCVFNGE PGAHDTKLCF ETQEVKGIGT PPNTTPIKNG SPEIKLKITK TYMNGKPLFE 120
SSICGDGAAD MSQSEENGQK SDNKTRRNRK RSIKYDSLLE QGLVEAALVS KISSPEDKKI 180
PVKKESCPNS GRDRDLLLKY NVGDLVWSKV SGYPWWPCMV SADPLLHNHT KLKGQKKSAR 240
QYHVQFFGDA PERAWIFEKS LVAFEGEEQF EKLCQESAKQ APTKAEKIKL LKPISGRLRA 300
QWEMGIVQAE EAASMSVEER KAKFTFLYVG DQLRLNPQVA KEAGIATEPL GEMVDSSVAN 360
EEAAVDPGTM REEDIPVKRR RRAKRSSSAE NQEGDPGTEK STPPKMADAE PKRGVGSPAG 420
RKRSTGSASR SRKGDSAAQF LVFCQKHRDE VVAEHPDASE EEIEELLGSQ WSMLNEKQKA 480
RYNTKFSLMI SAQSEEDSGN TSGKKRTHTK RTDDPPEDVD VEDAPRKRLR TDKHSLRKQR 540
ETITDKTART SSYKAIEAAS SLKSQAATKN LSDACKPLKK RNRASATASS ALGFNKSSSP 600
SASLTENEVS DNPGDEPSES PYESADETQT EASVSSKKSE RGMAAKKEYV CQLCEKTGSL 660
LLCEGPCCGA FHLACLGLSQ RPEGRFTCTE CASGIHSCFV CKESKMEVKR CMVNQCGKFY 720
HEACVKKYPL TVFESRGFRC PLHSCMSCHA SNPSNPRPSK GKMMRCVRCP VAYHGGDACL 780
AAGCSVIASN SIICTGHFTA RKGKRHHTHV NVSWCFVCSK GGSLLCCEAC PAAFHPDCLS 840
IEMPDGSWFC NDCRAGKKLH FQDIIWVKLG NYRWWPAEVC HPKNVPPNIQ KMKHEIGEFP 900
VFFFGSKDYY WTHQARVFPY MEGDRGSRYQ GVRGIGRVFK NALQEAEARF NEIKLQREAR 960
ETQESERKPP PYKHIKVNKP YGKVQIYTAD ISEIPKCNCK PTDENPCGSD SECLNRMLMF 1020
ECHPQVCPAG EYCQNQCFTK RQYPETKIIK TDGKGWGLVA KRDIRKGEFV NEYVGELIDE 1080
EECMARIKYA HENDITHFYM LTIDKDRIID AGPKGNYSRF MNHSCQPNCE TLKWTVNGDT 1140
RVGLFAVCDI PAGTELTFNY NLDCLGNEKT VCRCGASNCS GFLGDRPKTS TSLSSEEKSK 1200
KAKKKTRRRR AKGEGKRQSE DECFRCGDGG QLVLCDRKFC TKAYHLSCLG LGKRPFGKWE 1260
CPWHHCDVCG KPSTSFCHLC PNSFCKEHQD GTAFRSTQDG QSYCCEHDLR ADSANNTKTE 1320
KPFLDSLKAK GKRKKRRCWR RVTDGK 1346 
Gene Ontology
 GO:0031965; C:nuclear membrane; IEA:Compara.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0003289; P:atrial septum primum morphogenesis; IEA:Compara.
 GO:0003290; P:atrial septum secundum morphogenesis; IEA:Compara.
 GO:0060348; P:bone development; IEA:Compara.
 GO:0003149; P:membranous septum morphogenesis; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara. 
Interpro
 IPR006560; AWS.
 IPR009071; HMG_box_dom.
 IPR003616; Post-SET_dom.
 IPR000313; PWWP.
 IPR001214; SET_dom.
 IPR019786; Zinc_finger_PHD-type_CS.
 IPR011011; Znf_FYVE_PHD.
 IPR001965; Znf_PHD.
 IPR019787; Znf_PHD-finger.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF00505; HMG_box
 PF00628; PHD
 PF00855; PWWP
 PF00856; SET 
SMART
 SM00570; AWS
 SM00398; HMG
 SM00249; PHD
 SM00508; PostSET
 SM00293; PWWP
 SM00184; RING
 SM00317; SET 
PROSITE
 PS51215; AWS
 PS50118; HMG_BOX_2
 PS50868; POST_SET
 PS50812; PWWP
 PS50280; SET
 PS01359; ZF_PHD_1
 PS50016; ZF_PHD_2
 PS50089; ZF_RING_2 
PRINTS