CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024774
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ryanodine receptor 1 
Protein Synonyms/Alias
 RYR-1; RyR1; Skeletal muscle calcium release channel; Skeletal muscle ryanodine receptor; Skeletal muscle-type ryanodine receptor; Type 1 ryanodine receptor 
Gene Name
 Ryr1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
828RLHLQPIKEYRREGPacetylation[1]
2488DGALVQPKMSASFVPacetylation[1]
2919EKARDREKAQELLKFacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity). 
Sequence Annotation
 DOMAIN 99 154 MIR 1.
 DOMAIN 161 206 MIR 2.
 DOMAIN 212 266 MIR 3.
 DOMAIN 272 329 MIR 4.
 DOMAIN 337 394 MIR 5.
 DOMAIN 583 799 B30.2/SPRY 1.
 REPEAT 843 956 1.
 REPEAT 957 1070 2.
 DOMAIN 1015 1209 B30.2/SPRY 2.
 REPEAT 1345 1360 3; truncated.
 DOMAIN 1358 1571 B30.2/SPRY 3.
 REPEAT 1373 1388 4; truncated.
 REPEAT 2723 2842 5.
 REPEAT 2843 2956 6.
 REGION 843 2956 6 X approximate repeats.
 REGION 3613 3642 Interaction with CALM (By similarity).
 MOD_RES 2344 2344 Phosphoserine.
 MOD_RES 2840 2840 Phosphoserine; by PKA and PKG (By
 MOD_RES 3634 3634 S-nitrosocysteine (By similarity).
 MOD_RES 4861 4861 Phosphotyrosine (By similarity).
 MOD_RES 4864 4864 Phosphoserine (By similarity).  
Keyword
 Calcium; Calcium channel; Calcium transport; Calmodulin-binding; Complete proteome; Developmental protein; Ion channel; Ion transport; Ligand-gated ion channel; Membrane; Phosphoprotein; Receptor; Reference proteome; Repeat; S-nitrosylation; Sarcoplasmic reticulum; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 5035 AA 
Protein Sequence
MGDGGGEGED EVQFLRTDDE VVLQCSATVL KEQLKLCLAA EGFGNRLCFL EPTSNAQNVP 60
PDLAICCFIL EQSLSVRALQ EMLANTVEAG VESSQGGGHR TLLYGHAILL RHAHSRMYLS 120
CLTTSRSMTD KLAFDVGLQE DATGEACWWT MHPASKQRSE GEKVRVGDDL ILVSVSSERY 180
LHLSTASGEL QVDASFMQTL WNMNPICSCC EEGFVTGGHV LRLFHGHMDE CLTISPSDSD 240
DQRRLVYYEG GPVCTHARSL WRLEPLRISW SGSHLRWGQP LRIRHVTTGR YLALTEDQGL 300
VVVDASKAHT KATSFCFRIS KEKLDVAPKR DVEGMGPPEI KYGESLCFVQ HVASGLWLTY 360
AAPDPKALRL GVLKKKAMLH QEGHMDDALS LTRCQQEESQ AARMIYSTAG LYNQFIKGLD 420
SFSGKPRGSG PPAGSALPIE GVILSLQDLI GYFEPPSEEL QHEEKQTKLR SLRNRQSLFQ 480
EEGMLSLVLN CIDRLNVYTT AAHFAEFAGE EAAESWKEIV NLLYELLASL IRGNRTNCAL 540
FSTNLDWLVS KLDRLEASSG ILEVLYCVLI ESPEVLNIIQ ENHIKSIISL LDKHGRNHKV 600
LDVLCSLCVC NGVAVRSNQD LITENLLPGR ELLLQTNLIN YVTSIRPNIF VGRAEGSTQY 660
GKWYFEVMVD EVAPFLTAQA THLRVGWALS EGYSPYPGGG EGWGGNGVGD DLYSYGFDGL 720
HLWTGHVARP VTSPGQHLLG PEDVVSCCLD LSVPSISFRI NGCPVQGVFE SFNLDGLFFP 780
VVSFSAGIKV RFLLGGRHGE FKFLPPPGYA PCHEAVLPRE RLHLQPIKEY RREGPRGPHL 840
VGPSRCLSHL DFVPCPVDTI QIVLPPHLER IREKLAENIH ELWALTRIEQ GWTYGPVRDD 900
NKRLHPCLVD FHSLPEPERN YNLQMSGETL KTLLALGCHV GMADEKAEDN LKKTKLPKTY 960
MMNNGYKPAP LDLSHVRLTP AQTTLVDRLA ENGHNVWARD RVAQGWSYSA VQDIPARRNP 1020
RLVPYRLLDE ATKRSNRDSL CQAVRTLLGY GYNIEPPDQE PSQVDSQSRG DRARIFRAEK 1080
SYAVQSGRWY FEFEAVTTGR ELGWARPELR PDVELGADDL AYVFNGHRGQ RWHLGSEPFG 1140
RPWQSGDVVG CMIDLTENTI IFTLNGEVLM SDSGSETAFR EIEIGDGFLP VCSLGPGQVG 1200
HLNLGQDVSS LRFFAICGLQ EGFEPFAINM QRPVTTWFSK SLPQFEPVPL EHPHYEVARM 1260
DGTVDTPPCL RLTHRTWGSQ NSLVEMLFLR LSLPVQFHQH FRCTAGATPL ASPGLQPPAE 1320
DEARAAEPDT DYENLRRSAG GWGEAEAGKD GTAKEGTPGG AAQPGVEAQP ARAENEKDAT 1380
TEKNKKRGFL FKAKKVAMMT QPPSTPALPR LPRDVVPADN RDDPEIILNT TTYYYSVRVF 1440
AGQEPSCVWV GWVTPDYHQH DMSFDLSKVR AVTVTMGDEQ GNVHSSLKCS NCYMVWGGDF 1500
VSPGQQGRIS HTDLVIGCLV DLATGLMTFT ANGKESNTFF QVEPNTKLFP AVFVLPTHQN 1560
VVQFDLRPGA NIMPLSAAMF LSERKNPAPQ CPPRLEVQML MPVSWSRMPN HFLHVDTRRA 1620
GERLGWAVQC QEPLMMMALH IPEENSEPYI HLKRAQLDPR DLRDYRDTKF DSESSDSDQT 1680
PQPGCYHVDQ AQLLHALEDA HLPGPLRAGY YDLLISIHLE SACRSRRSML SEYIVPLTEE 1740
TRAITLFPPG RSAEDGPRRH GLPGVGVTTS LRPPHHFSPP CFVVALPAAG AAEAPARLSP 1800
AIPLEALRDK ALRMLGEAVR DGGQHARDPV GGSVEFQFVP VLKLVSTLLV MGVFSDEDVK 1860
QILKMIEPEV FTEEEEVEEE EEEEEEDEEE KEEDEEEEAH EKEDEEKEEA EEAAEEEKEE 1920
LEEGLLQMKL PESVKLQMCH LLEYFCDQEL QHRVESLAAF AERYVDKLQS NQRGRYGLLM 1980
KAFTMSAAET ARRTREFRSP PQEQINMLLQ FKNGADEEDC PLPEEIREDL VNFHQDLLAH 2040
CGIQLEGEEE EPEEESTLGS RLMSLLEKVR LVKKKEEKPE EEPAAEEHKP QSLQELVSHT 2100
VVRWAQEDFV QSPELVRAMF SLLHRQYDGL GELLRALPRA YTISLSSVED TMSLLECLGQ 2160
IRSLLIVQMG PQEENLMIQS IGNIMNNKVF YQHPNLMRAL GMHETVMEVM VNVLGGGESK 2220
EIRFPKMVTS CCRFLCYFCR ISRQNQRSMF DHLSYLLENS GIGLGMQGST PLDVAAASVI 2280
DNNELALALQ EQDLEKVVSY LAGCGLQSCP MLLAKGYPDI GWNPCGGERY LDFLRFAVFV 2340
NGESVEENAN VVVRLLIRKP ECFGPALRGE GGSGLLAAIE EAIRISEDPA RDGPGVRRDR 2400
RREHFGEEPP EENRVHLGHA IMSFYAALID LLGRCAPEMH LIQAGKGEAL RIRAILRSLV 2460
PLDDLVGIIS LPLQIPTLGK DGALVQPKMS ASFVPDHKAS MVLFLDRVYG IENQDFLLHV 2520
LDVGFLPDMR AAASLDTATF SRRWALALTR YLCAVLPLIT KCAPLLRGTE HRAIMVDSML 2580
HTVYRLSRGR SLTKAQRDVI EDCLMALCRY IRPSMLQHLL RRLVFDVPIL NEFAKMPLKL 2640
LTNHYERCWK YYCLPTGWAN FGVTSEEELH LTRKLFWGIF DSLAHKKYDQ ELYRIAMPCL 2700
CAIAGALPPD YVDASYSSKT EKKATVDAEG NFDPRPVETL NVIIPEKLDS FINKFAEYAH 2760
EKWAFDKIQN NWSYGENIDE ELKTHPMLRP YKTFSEKDKE IYRWPIKESL KAMIAWEWTV 2820
EKAREGEEEK TEKKKTRKIS QTAQTYDPRE GYNPQPPDLS VVTLSRELQA MAEQLAENYH 2880
NTWGRKKKQE LEAKGGGSHP LLVPYDTLTA KEKARDREKA QELLKFLQMN GYAVTRHGKD 2940
MELDTSSIEK RFAFGFLQQL LRWMDISQEF IAHLEAVVSS GRVEKSPHEQ EIKFFAKILL 3000
PLINQYFTNH CLYFLSTPAK VLGSGGHASN KEKEMITSLF CKLAALVRHR VSLFGTDAPA 3060
VVNCLHILAR SLDARTVMKS GPEIVKAGLR SFFESASEDI EKMVENLRLG KVSQARTQVK 3120
GVGQNLTYTT VALLPVLTTL FQHIAQHQFG DDVILDDVQV SCYRTLCSIY SLGTTRNPYV 3180
EKLRPALGEC LARLAAAMPV AFLEPELNEY NACSVYTTKS PRERAILGLP NSVEEMCPDI 3240
PVLERLMAEI GGLAESGARY TEMPHVIEIT LPMLCSYLPR WWERGPEAPP PALPAGAPPP 3300
CTAVTSDHLN SLLGNILRII VNNLGIDEAS WMKRLAVFAQ PIVSRARPEL LRSHFIPTIG 3360
RLRKRAGKVV AEEEQLRLEA KAEAEEGELL VRDEFSVLCR DLYALYPLLI RYVDNNRSAW 3420
PRLPPSPSSS FSLPSPSELG RWLMKDHGHQ LYEESFTVPL ILDNAAFPLA RNQSRAIGCA 3480
GVVRSGGSDQ ERTKKKRRGD RYSVQTSLIV ATLKKMLPIG LNMCAPTDQD LIVLAKARYA 3540
LKDTDEEVRE FLQNNLNLQG KVEGSPSLRW QMALYRGVPG REEDADDPEK IVRRVQEVSA 3600
VLYHLDQTEH PYKSKKAVWH KLLSKQRRRA VVACFRMTPL YNLPTHRACN MFLESYKASW 3660
ILTEDHSFED RMIDDLSKAG EQEEEEEEVE EKKPDPLHQL VLHFSRTALT EKSKLDEDYL 3720
YMAYADIMAK SCHLEEGGEN VEEGGEEEEV EVSFEEKEME KQRLLYQQSR LHNRGAAEMV 3780
LQMISACKGE TGAMVSSTLK LGISILNGGN AEVQQKMLDY LKDKKEVGFF QSIQALMQTC 3840
RWPHKTLSQR EGQEERVMKV QTSGTLVIIN RQNGEKVMAD DEFTQDLFRF LQLLCEGHNN 3900
DFQNYLRTQT GNTTTINIII CTVDYLLRLQ ESISDFYWYY SGKDVIEEQG KRNFSKAMSV 3960
AKQVFNSLTE YIQGPCTGNQ QSLAHSRLWD AVVGFLHVFA HMMMKLAQDS SQIELLKELL 4020
DLQKDMVVML LSLLEGNVVN GMIARQMVDM LVESSSNVEM ILKFFDMFLK LKDIVGSEAF 4080
QDYVTDPRGL ISKKDFQKAM DSQKQFTGPE IQFLLSCSEA DENEMINCEE FANRFQEPAR 4140
DIGFNVAVLL TNLSEHVPHD PRLRNFLELA ESILDYFRPY LGRIEIMGAS RRIERIYFEI 4200
SETNRAQWEM PQVKESKRQF IFDVVNEGGE SEKMELFVSF CEDTIFEMQI AAQISEPEGE 4260
PEEDDDEGAE EAEEGAAGPD GSGSAAAAGV WTWLATAAGR TLRGLSYRSL RRRVRRLRRL 4320
TAREAATAVA VLLWAMVARA GGAGAGAAAG VLRLLWGSLF GGGLVDSAKK VTVTELLAGM 4380
PDPTGDEVHG QQPSGAGSDA EGEGQGEGEG DAAEGVGDEE VAADQAGTGG ADRTVAVADG 4440
SPFRPEGAGG LGDMGDTTPV EPPTPEGSPI LKRKLGVDGE EEEPQPEPEP EPEPEPEKAD 4500
TENGEKEVPE PPPEPPKKAP PPPPPKKEEA GGAGLEEFWG ELEVQRVKFL NYLSRNFYTL 4560
RFLALFLAFA INFILLFYKV SDSPPGEDDI EGSGAGDMSG AGSGDGSGWG SRASEEVEGD 4620
EDENMVYYFL EESTGYMEPA LRCLSLLHTL VAFLCIIGYN CLKVPLVIFK REKELARKLE 4680
FDGLYITEQP EDDDVKGQWD RLVLNTPSFP SNYWDKFVKR KVLDKHGDIF GRERIAELLG 4740
MDLASLEITA HNERKPDPPP GLLTWIMSID VKYQIWKFGV IFTDNSFLYL GWYMVMSLLG 4800
HYNNFFFAAH LLDIAMGVKT LRTILSSVTH NGKQLVMTVG LLAVVVYLYT VVAFNFFRKF 4860
YNKSEDEDEP DMKCDDMMTC YLFHMYVGVR AGGGIGDEIE DPAGDEYELY RVVFDITFFF 4920
FVIVILLAII QGLIIDAFGE LRDQQEQVKE DMETKCFICG IGSDYFDTTP HGFETHTLEE 4980
HNLANYMFFL MYLINKDETE HTGQESYVWK MYQERCWDFF PAGDCFRKQY EDQLG 5035 
Gene Ontology
 GO:0005938; C:cell cortex; IEA:Compara.
 GO:0031234; C:extrinsic to internal side of plasma membrane; IDA:RGD.
 GO:0031674; C:I band; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0030314; C:junctional membrane complex; IEA:Compara.
 GO:0042383; C:sarcolemma; IDA:RGD.
 GO:0033017; C:sarcoplasmic reticulum membrane; IDA:UniProtKB.
 GO:0030315; C:T-tubule; IEA:Compara.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005219; F:ryanodine-sensitive calcium-release channel activity; ISS:UniProtKB.
 GO:0005245; F:voltage-gated calcium channel activity; ISS:UniProtKB.
 GO:0071313; P:cellular response to caffeine; ISS:UniProtKB.
 GO:0006936; P:muscle contraction; ISS:UniProtKB.
 GO:0043931; P:ossification involved in bone maturation; ISS:UniProtKB.
 GO:0003151; P:outflow tract morphogenesis; ISS:UniProtKB.
 GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; ISS:UniProtKB.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0048741; P:skeletal muscle fiber development; ISS:UniProtKB.
 GO:0043588; P:skin development; ISS:UniProtKB. 
Interpro
 IPR001870; B30.2/SPRY.
 IPR000699; Ca-rel_channel.
 IPR008985; ConA-like_lec_gl_sf.
 IPR011992; EF-hand-like_dom.
 IPR014821; Ins145_P3_rcpt.
 IPR005821; Ion_trans_dom.
 IPR016093; MIR_motif.
 IPR013662; RIH_assoc-dom.
 IPR013333; Ryan_recept.
 IPR003032; Ryanodine_rcpt.
 IPR015925; Ryanodine_recept-rel.
 IPR009460; Ryanrecept_TM4-6.
 IPR018355; SPla/RYanodine_receptor_subgr.
 IPR003877; SPRY_rcpt. 
Pfam
 PF08709; Ins145_P3_rec
 PF00520; Ion_trans
 PF02815; MIR
 PF08454; RIH_assoc
 PF06459; RR_TM4-6
 PF01365; RYDR_ITPR
 PF02026; RyR
 PF00622; SPRY 
SMART
 SM00472; MIR
 SM00449; SPRY 
PROSITE
 PS50188; B302_SPRY
 PS50919; MIR 
PRINTS
 PR00795; RYANODINER.