UniProt Accession

 PAX1_HUMAN; P15863; B4E0D6; Q642X9; Q6NTC0; Q9Y558 

Genbank Protein ID

 AK303335; AY740018; AL035562; AL035562; BC069134; X15044 

Genbank Nucleotide ID

 BAG64398.1; AAU21037.1; CAX12115.1; CAB46996.2; AAH69134.1; CAA33146.1 

Protein Name

 Paired box protein Pax-1 

Protein Synonyms/Alias

 HuP48 

Gene Name

 PAX1 

Gene Synonyms/Alias

 HUP48 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
208	LADGVCDKYNVPSVS	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal development of the vertebral column (By similarity). 

Sequence Annotation

 DOMAIN 98 224 Paired.  

Keyword

 Activator; Alternative splicing; Complete proteome; Developmental protein; DNA-binding; Nucleus; Paired box; Polymorphism; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 534 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0060349; P:bone morphogenesis; IEA:Compara.
 GO:0043367; P:CD4-positive, alpha-beta T cell differentiation; IEA:Compara.
 GO:0043374; P:CD8-positive, alpha-beta T cell differentiation; IEA:Compara.
 GO:0008283; P:cell proliferation; IEA:Compara.
 GO:0060017; P:parathyroid gland development; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0061056; P:sclerotome development; IEA:Compara.
 GO:0001501; P:skeletal system development; TAS:ProtInc.
 GO:0001756; P:somitogenesis; IEA:Compara.
 GO:0048538; P:thymus development; IEA:Compara.
 GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc. 

Interpro

 IPR009057; Homeodomain-like.
 IPR001523; Paired_dom.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00292; PAX 

SMART

 SM00351; PAX 

PROSITE

 PS00034; PAIRED_1
 PS51057; PAIRED_2 

PRINTS

 PR00027; PAIREDBOX.