UniProt Accession

 DHB11_MOUSE; Q9EQ06; Q3U2P6; Q8BR33; Q8C7S0 

Genbank Protein ID

 AF304306; AY053570; AK049355; AK154803; AK155174; AK155202; AK155327; AK158327; AK170939; BC038340 

Genbank Nucleotide ID

 AAG41413.1; AAL14859.1; BAC33704.1; BAE32840.1; BAE33094.1; BAE33115.1; BAE33194.1; BAE34459.1; BAE42129.1; AAH38340.1 

Protein Name

 Estradiol 17-beta-dehydrogenase 11 

Protein Synonyms/Alias

 17-beta-hydroxysteroid dehydrogenase 11; 17-beta-HSD 11; 17bHSD11; 17betaHSD11; 17-beta-hydroxysteroid dehydrogenase XI; 17-beta-HSD XI; 17betaHSDXI; Dehydrogenase/reductase SDR family member 8 

Gene Name

 Hsd17b11 

Gene Synonyms/Alias

 Dhrs8; Pan1b 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
58	LTAYEFAKLNTKLVL	ubiquitination	[1]
62	EFAKLNTKLVLWDIN	ubiquitination	[1]
70	LVLWDINKNGIEETA	ubiquitination	[1]
82	ETAAKCRKLGAQAHP	ubiquitination	[1]
105	EEIYSAAKKVKEEVG	ubiquitination	[1]
296	FDAVVGYKDK*****	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Can convert androstan-3-alpha,17-beta-diol (3-alpha- diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. 

Sequence Annotation

 NP_BIND 40 64 NADP (By similarity).
 ACT_SITE 185 185 Proton acceptor (By similarity).
 BINDING 172 172 Substrate (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Lipid biosynthesis; Lipid metabolism; NADP; Oxidoreductase; Reference proteome; Secreted; Signal; Steroid biosynthesis. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 298 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0005811; C:lipid particle; IEA:Compara.
 GO:0004303; F:estradiol 17-beta-dehydrogenase activity; IEA:EC.
 GO:0006710; P:androgen catabolic process; IEA:Compara.
 GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW. 

Interpro

 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF00106; adh_short 

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS

 PR00081; GDHRDH.
 PR00080; SDRFAMILY.