CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016885
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Translation initiation factor eIF-2B subunit epsilon 
Protein Synonyms/Alias
 eIF-2B GDP-GTP exchange factor subunit epsilon 
Gene Name
 Eif2b5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
477EKEKVKLKGYNPAEVubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP (By similarity). 
Sequence Annotation
 DOMAIN 539 716 W2.
 MOD_RES 540 540 Phosphoserine; by DYRK2.
 MOD_RES 713 713 Phosphoserine.
 MOD_RES 714 714 Phosphoserine.  
Keyword
 Complete proteome; Initiation factor; Phosphoprotein; Protein biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 717 AA 
Protein Sequence
MAATAAVPGA AAGRASKRGG GGSGGGGTQG AEEEPPPPLQ AVLVADSFNR RFFPISKDQP 60
RVLLPLANVA LIDYTLEFLT ATGVQETFVF CCWKAAQIKE HLQKSKWCHP TSPNVVRIIT 120
SELYRSLGDV LRDVDAKALV RSDFLLIYGD VISNINICRA LEEHRLRRKL EKNVSVMTMV 180
FKESSPSHPT RCHEDNVVMA VDSATNRVLH FQKTQGLRRF SFPLSLFQGS GDGVEIRYDL 240
LDCHISICSP QVAQLFTDNF DYQTRDDFVR GILMNEEVLG NQIHLHVTTR EYGARVSNLH 300
MYSAVCADVI RRWVYPLTPE VNFTDSTTQS YTHSRHNIYR GPEVSLGHGS VLEENVLLGA 360
GTVIGSNCSI TNSVIGPNCH IGDNVVLDQA YLWQGVRVAA GAQIHQSLLC DRAEVKERVK 420
LKPYCVLTSQ VVVGPDITLP EGSVISLHPP DAEEDEDDGQ FSDDSGADQE KEKVKLKGYN 480
PAEVGLEGQG YLWKAEGVNS KEDEELRQSL WGLMIKTEEE SETESEGSVD PEELDSRAGS 540
PQLDDIRVFQ NEVLGTLQRG REENISCENL VLEINSLKHA YNISLKEVMQ VLTLVVLEFP 600
LQQVDGLLDP NRYCALLLPL LKAWSPVLRN YIKRAADHLE ALAAIEDFFL EHETLVTSMA 660
KVLMAFYQLE ILAEETILSW FSQRDTTDEG QQLRKNQQLQ RFIQWLREAE EESSEDD 717 
Gene Ontology
 GO:0005851; C:eukaryotic translation initiation factor 2B complex; ISS:UniProtKB.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0016740; F:transferase activity; IEA:InterPro.
 GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
 GO:0014002; P:astrocyte development; ISS:UniProtKB.
 GO:0051716; P:cellular response to stimulus; ISS:UniProtKB.
 GO:0042552; P:myelination; ISS:UniProtKB.
 GO:0032057; P:negative regulation of translational initiation in response to stress; IEA:Compara.
 GO:0014003; P:oligodendrocyte development; ISS:UniProtKB.
 GO:0001541; P:ovarian follicle development; ISS:UniProtKB.
 GO:0045948; P:positive regulation of translational initiation; ISS:UniProtKB.
 GO:0009749; P:response to glucose stimulus; ISS:UniProtKB.
 GO:0009408; P:response to heat; ISS:UniProtKB.
 GO:0043434; P:response to peptide hormone stimulus; ISS:UniProtKB.
 GO:0016070; P:RNA metabolic process; IEA:InterPro.
 GO:0006413; P:translational initiation; ISS:UniProtKB. 
Interpro
 IPR016024; ARM-type_fold.
 IPR001451; Hexapep_transf.
 IPR016021; MIF4-like_typ_1/2/3.
 IPR011004; Trimer_LpxA-like.
 IPR003307; W2_domain. 
Pfam
 PF00132; Hexapep
 PF02020; W2 
SMART
 SM00515; eIF5C 
PROSITE
 PS51363; W2 
PRINTS