| Tag | Content |
|---|
| CPLM ID | CPLM-016632 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Rhophilin-2 |
Protein Synonyms/Alias | GTP-Rho-binding protein 2 |
Gene Name | Rhpn2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 576 | LTVSEVMKLLKSFGG | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity (By similarity). |
Sequence Annotation | REPEAT 38 110 REM.
DOMAIN 111 502 BRO1.
DOMAIN 515 593 PDZ.
REGION 46 66 Interaction with Rho (By similarity). |
Keyword | 3D-structure; Complete proteome; Cytoplasm; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 686 AA |
Protein Sequence | MTDTLLPAAP QPLEKEGDDY FRKGCNPLAQ TGRSKLQNQR AALNQQILKA VRMRTGAENL 60
LKVATNQKVR EQVRLELSFV NSDLQMLKEE LEGLNISVGV YQGTEEAFTI PLIPLGLKET 120
KEVDFSIVFK DFILEHYSED SYLYEDDIAD LMDLRQACRT PSRDEAGVEL LMSYFIQLGF 180
VESRFFPPTR HMGLLFTWYD SFTGVPVSQQ TLLLEKASVL FNIGALYTQI GTRCNRQTQA 240
GLESAVDAFQ RAAGVLNYLK ETFTHTPSYD MSPAMLSVLV KMMLAQAQES VFEKVCLPGI 300
QNEFFVLVKV AQEAAKVAEA YRQLHAAMSQ EPVKENIPYS WASVAYVKAY HYGALAHYFA 360
ATLLIDHQLK PGADEDHQEK CLSQLYDRMP EGMTPLATLK NAGQRVLLGK GHLHRAIGFH 420
EESLREANLC KKLRDIQVLR DVLSAAHQRT QLKHTQHRED DDLLNLIDAP DVLPKTEREV 480
KITFPDFSKV TVTDFFQKLG PLSVFSASKR WSPPRGIHFT VEEGDLGFTL RGNTPVQVHF 540
LDPHCSASLA GAKEGDYIVS IQGVDCKWLT VSEVMKLLKS FGGEEVEMKV VSLLDSTSSM 600
HNKCATYSVG MQKTYSMICL SMDDDDKADK TKKISKKLSF LSWGTSKNRQ KSASTLCLPE 660
VGLARSQNKK KLPTPFSLLN SDSSLY 686 |
Gene Ontology | GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. GO:0007165; P:signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |