UniProt Accession

 RMLC_ECOLI; P37745 

Genbank Protein ID

 U03041; U09876; U00096; AP009048 

Genbank Nucleotide ID

 AAC31630.1; AAB88401.1; AAC75099.1; BAA15880.1 

Protein Name

 dTDP-4-dehydrorhamnose 3,5-epimerase 

Protein Synonyms/Alias

 Thymidine diphospho-4-keto-rhamnose 3,5-epimerase; dTDP-4-keto-6-deoxyglucose 3,5-epimerase; dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase; dTDP-L-rhamnose synthase 

Gene Name

 rfbC 

Gene Synonyms/Alias

 rmlC; b2038; JW2023 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
72	RGEYAQDKLVRCTHG	acetylation	[1]
168	SGLILSPKDERLFTL	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose (By similarity). 

Sequence Annotation

 REGION 168 169 Substrate binding (By similarity).
 BINDING 23 23 Substrate (By similarity).
 BINDING 28 28 Substrate (By similarity).
 BINDING 47 47 Substrate (By similarity).
 BINDING 49 49 Substrate (By similarity).
 BINDING 59 59 Substrate (By similarity).
 BINDING 62 62 Substrate (By similarity).
 BINDING 72 72 Substrate (By similarity).
 BINDING 83 83 Substrate (By similarity).
 BINDING 119 119 Substrate (By similarity).  

Keyword

 Complete proteome; Isomerase; Lipopolysaccharide biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 185 AA 

Protein Sequence

Gene Ontology

 GO:0008830; F:dTDP-4-dehydrorhamnose 3,5-epimerase activity; ISS:UniProtKB.
 GO:0019305; P:dTDP-rhamnose biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0045226; P:extracellular polysaccharide biosynthetic process; ISS:UniProtKB.
 GO:0009103; P:lipopolysaccharide biosynthetic process; ISS:UniProtKB.
 GO:0009243; P:O antigen biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0046677; P:response to antibiotic; IMP:EcoCyc.
 GO:0006974; P:response to DNA damage stimulus; IMP:EcoCyc. 

Interpro

 IPR000888; dTDP_sugar_isom.
 IPR014710; RmlC-like_jellyroll.
 IPR011051; RmlC_Cupin. 

Pfam

 PF00908; dTDP_sugar_isom 

SMART

  

PROSITE

  

PRINTS