UniProt Accession

 PSA6_MOUSE; Q9QUM9; Q0VGS3; Q3TT07; Q3U6Y2 

Genbank Protein ID

 U60288; AF060087; AK088143; AK152915; AK161662; BC086685 

Genbank Nucleotide ID

 AAF21459.1; AAD50532.1; BAC40169.1; BAE31592.1; BAE36518.1; AAH86685.1 

Protein Name

 Proteasome subunit alpha type-6 

Protein Synonyms/Alias

 Macropain iota chain; Multicatalytic endopeptidase complex iota chain; Proteasome iota chain 

Gene Name

 Psma6 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
45	TSVAVRGKDCAVIVT	ubiquitination	[1]
55	AVIVTQKKVPDKLLD	ubiquitination	[1]
102	RYEAANWKYKYGYEI	ubiquitination	[1]
171	KATAAGVKQTESTSF	ubiquitination	[1]
181	ESTSFLEKKVKKKFD	acetylation	[2]
181	ESTSFLEKKVKKKFD	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. 

Sequence Annotation

 MOD_RES 102 102 N6-acetyllysine (By similarity).
 MOD_RES 104 104 N6-acetyllysine (By similarity).
 MOD_RES 159 159 Phosphotyrosine.
 CARBOHYD 5 5 O-linked (GlcNAc...).
 CROSSLNK 59 59 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Glycoprotein; Hydrolase; Isopeptide bond; Nucleus; Phosphoprotein; Protease; Proteasome; Reference proteome; Threonine protease; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 246 AA 

Protein Sequence

Gene Ontology

 GO:0000932; C:cytoplasmic mRNA processing body; IDA:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0016363; C:nuclear matrix; IDA:BHF-UCL.
 GO:0005844; C:polysome; ISS:BHF-UCL.
 GO:0019773; C:proteasome core complex, alpha-subunit complex; ISS:BHF-UCL.
 GO:0030017; C:sarcomere; ISS:BHF-UCL.
 GO:0003723; F:RNA binding; IDA:BHF-UCL.
 GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
 GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:BHF-UCL.
 GO:0051603; P:proteolysis involved in cellular protein catabolic process; ISS:BHF-UCL.
 GO:0007519; P:skeletal muscle tissue development; NAS:BHF-UCL.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. 

Interpro

 IPR000426; Proteasome_asu_N.
 IPR023332; Proteasome_suA-type.
 IPR001353; Proteasome_sua/b. 

Pfam

 PF00227; Proteasome
 PF10584; Proteasome_A_N 

SMART

 SM00948; Proteasome_A_N 

PROSITE

 PS00388; PROTEASOME_A_1
 PS51475; PROTEASOME_A_2 

PRINTS