CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002657
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Homoserine O-acetyltransferase 
Protein Synonyms/Alias
 Homoserine O-trans-acetylase 
Gene Name
 MET2 
Gene Synonyms/Alias
 YNL277W; N0615 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
352YLRYQGTKFINRFDAacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919
Functional Description
  
Sequence Annotation
 ACT_SITE 162 162 Potential.
 ACT_SITE 430 430 Potential.  
Keyword
 Acyltransferase; Amino-acid biosynthesis; Complete proteome; Methionine biosynthesis; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 486 AA 
Protein Sequence
MSHTLKSKTL QELDIEEIKE TNPLLKLVQG QRIVQVPELV LESGVVINNF PIAYKTWGTL 60
NEAGDNVLVI CHALTGSADV ADWWGPLLGN DLAFDPSRFF IICLNSMGSP YGSFSPLTIN 120
EETGVRYGPE FPLCTVRDDV RAHRIVLDSL GVKSIACVIG GSMGGMLSLE WAAMYGKEYV 180
KNMVALATSA RHSAWCISWS EAQRQSIYSD PNYLDGYYPV EEQPVAGLSA ARMSALLTYR 240
TRNSFENKFS RRSPSIAQQQ KAQREETRKP STVSEHSLQI HNDGYKTKAS TAIAGISGQK 300
GQSVVSTASS SDSLNSSTSM TSVSSVTGEV KDIKPAQTYF SAQSYLRYQG TKFINRFDAN 360
CYIAITRKLD THDLARDRVD DITEVLSTIQ QPSLIIGIQS DGLFTYSEQE FLAEHIPKSQ 420
LEKIESPEGH DAFLLEFKLI NKLIVQFLKT NCKAITDAAP RAWGGDVGND ETKTSVFGEA 480
EEVTNW 486 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0004414; F:homoserine O-acetyltransferase activity; IMP:SGD.
 GO:0009092; P:homoserine metabolic process; IDA:SGD.
 GO:0009086; P:methionine biosynthetic process; IMP:SGD. 
Interpro
 IPR000073; AB_hydrolase_1.
 IPR008220; Homoserine_AcTrfase. 
Pfam
 PF00561; Abhydrolase_1 
SMART
  
PROSITE
  
PRINTS