CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023433
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 COP9 signalosome complex subunit 1b 
Protein Synonyms/Alias
 Dch1-2; Signalosome subunit 1b 
Gene Name
 CSN1b 
Gene Synonyms/Alias
 CG3889 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
496LKSHIHVKSISREGGacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in oogenesis and embryogenesis and is required for proper photoreceptor R cell differentiation and promote lamina glial cell migration or axon targeting. It also promotes Ubl-dependent degradation of cyclin E (CycE) during early oogenesis. 
Sequence Annotation
 DOMAIN 289 457 PCI.  
Keyword
 Complete proteome; Cytoplasm; Developmental protein; Differentiation; Nucleus; Oogenesis; Reference proteome; Signalosome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 525 AA 
Protein Sequence
MPVLPMPPLM QNAVEPMQVD IAPPNEDNEN NEEQQIVVEN PSIDLEVYAN QYAGIVRLHR 60
LIYVADVCPV LAVEALKMAI TYVQTTYNVN LYQVLHKRLS DLNAGNAPAP PANAGGDQAG 120
AAAPGPLAAA PLPDIAAQPV AQAQGQAQPA VEKDAFAYDA AWVDTKMKKA ALKLEKLDSD 180
LKNYKSNSIK ESIRRGHDDL ADHYLSCGDL TNALKCYSRA RDYCTSGKHV VNMCLNVIKV 240
SIYLQNWAHV MSYISKAEST PDFAEGSKEA NAQVHTRLEC AAGLAELQQK KYKVAAKHFL 300
NANFDHCDFP EMISTSNVAV YGGLCALATF DRQELKRLVI ASTSFKLFLE LEPQLRDIIF 360
KFYESKYASC LTLLDEIRDN LLVDMYIAPH VTTLYTKIRN RALIQYFSPY MSADMHKMAM 420
AFNSSVGDLE NEVMQLILDG QIQARIDSHN KILFAKEADQ RNSTFERALI MGKQYQRHTR 480
MLVLRAAMLK SHIHVKSISR EGGSNHGAEL CVSAGSSTTA QLARI 525 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0008180; C:signalosome; IMP:UniProtKB.
 GO:0019781; F:NEDD8 activating enzyme activity; IMP:UniProtKB.
 GO:0046331; P:lateral inhibition; IMP:FlyBase.
 GO:0007095; P:mitotic G2 DNA damage checkpoint; IGI:FlyBase.
 GO:0022008; P:neurogenesis; IMP:FlyBase.
 GO:0048477; P:oogenesis; IEA:UniProtKB-KW.
 GO:0000338; P:protein deneddylation; IMP:UniProtKB.
 GO:0050821; P:protein stabilization; IMP:FlyBase. 
Interpro
 IPR019585; 26S_proteasome_reg_su-Rpn7.
 IPR000717; PCI_dom.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF01399; PCI
 PF10602; RPN7 
SMART
 SM00088; PINT 
PROSITE
  
PRINTS