| Tag | Content |
|---|
| CPLM ID | CPLM-017775 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Bifunctional apoptosis regulator |
Protein Synonyms/Alias | |
Gene Name | Bfar |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 93 | LLRDAIEKLFPDAIR | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors (By similarity). |
Sequence Annotation | DOMAIN 182 249 SAM.
ZN_FING 34 74 RING-type.
CARBOHYD 232 232 N-linked (GlcNAc...) (Potential).
CARBOHYD 308 308 N-linked (GlcNAc...) (Potential). |
Keyword | 3D-structure; Alternative splicing; Apoptosis; Complete proteome; Endoplasmic reticulum; Glycoprotein; Membrane; Metal-binding; Reference proteome; Transmembrane; Transmembrane helix; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 450 AA |
Protein Sequence | MEEPQKNDLS MREQEEEHPV RSSGPQISVS EFSCHCCYDT LVNPTTLNCG HSFCRHCLAL 60
WWMSSKKTEC PECREKWEGF PKVNILLRDA IEKLFPDAIR MRVEDIQQNN DVVQSLAAFQ 120
KYGNDQNPLA PSTGRVNPQR GGGFFSGVLT ALTGVAVILL VYHWRSRESE HGLLVHKAVD 180
KWTMEEVVLW LEQLGPWASL YRDRFLSERV NGRLLLTLTE EEFSRAPYTI ENSSHRRVIL 240
TELERVRALG VKPPQNLWEY KAVNPGRSLF LLYALKSSPR LGLLYLYLFD YTDCFLPFIH 300
TICPLQENSS GEDIFTKLLD LREPTWKQWR EFLVKYSFLP YQLIAEFAWD WLEVHYWTSR 360
FLIVNAVLLS VLELFSFWRI WSRSELKTVP QRMWSHFWKV STQGLFMAMF WPLIPQFVCN 420
CLFYWALYFN PIINIDLVVK EVRRLETQVL 450 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0043066; P:negative regulation of apoptotic process; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |