CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031718
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DNA excision repair protein ERCC-6-like 
Protein Synonyms/Alias
 FLJ20105 protein, isoform CRA_a 
Gene Name
 ERCC6L 
Gene Synonyms/Alias
 FLJ20105; hCG_1642107 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
116KIKTSSTKSAICARAubiquitination[1]
164LGTLKTFKMEYENPIubiquitination[1]
184KDATPGEKALGFKISubiquitination[1]
189GEKALGFKISENLMAubiquitination[1]
199ENLMAIIKPYFLRRTubiquitination[1]
225PEARLNEKNPDVDAIubiquitination[1]
260LQEEIYRKFVSLDHIubiquitination[1, 2]
268FVSLDHIKELLMETRubiquitination[1]
286AELGVLKKLCDHPRLubiquitination[1]
347IFLMDLLKRLRDEGHubiquitination[1]
453RVYRIGQKENVVVYRubiquitination[1, 3]
478IYRRQVFKDSLIRQTubiquitination[1]
498NPFRYFSKQELRELFubiquitination[1, 2, 3]
762GPNLDQLKDDEILRHubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1127 AA 
Protein Sequence
MGLGKTVQII AFLSGMFDAS LVNHVLLIMP TNLINTWVKE FIKWTPGMRV KTFHGPSKDE 60
RTRNLNRIQQ RNGVIITTYQ MLINNWQQLS SFRGQEFVWD YVILDEAHKI KTSSTKSAIC 120
ARAIPASNRL LLTGTPIQNN LQELWSLFDF ACQGSLLGTL KTFKMEYENP ITRAREKDAT 180
PGEKALGFKI SENLMAIIKP YFLRRTKEDV QKKKSSNPEA RLNEKNPDVD AICEMPSLSR 240
KNDLIIWIRL VPLQEEIYRK FVSLDHIKEL LMETRSPLAE LGVLKKLCDH PRLLSARACC 300
LLNLGTFSAQ DGNEGEDSPD VDHIDQVTDD TLMEESGKMI FLMDLLKRLR DEGHQTLVFS 360
QSRQILNIIE RLLKNRHFKT LRIDGTVTHL LEREKRINLF QQNKDYSVFL LTTQVGGVGL 420
TLTAATRVVI FDPSWNPATD AQAVDRVYRI GQKENVVVYR LITCGTVEEK IYRRQVFKDS 480
LIRQTTGEKK NPFRYFSKQE LRELFTIEDL QNSVTQLQLQ SLHAAQRKSD IKLDEHIAYL 540
QSLGIAGISD HDLMYTCDLS VKEELDVVEE SHYIQQRVQK AQFLVEFESQ NKEFLMEQQR 600
TRNEGAWLRE PVFPSSTKKK CPKLNKPQPQ PSPLLSTHHT QEEDISSKMA SVVIDDLPKE 660
GEKQDLSSIK VNVTTLQDGK GTGSADSIAT LPKGFGSVEE LCTNSSLGME KSFATKNEAV 720
QKETLQEGPK QEALQEDPLE SFNYVLSKST KADIGPNLDQ LKDDEILRHC NPWPIISITN 780
ESQNAESNVS IIEIADDLSA SHSALQDAQA SEAKLEEEPS ASSPQYACDF NLFLEDSADN 840
RQNFSSQSLE HVEKENSLCG SAPNSRAGFV HSKTCLSWEF SEKDDEPEEV VVKAKIRSKA 900
RRIVSDGEDE DDSFKDTSSI NPFNTSLFQF SSVKQFDAST PKNDISPPGR FFSSQIPSSV 960
NKSMNSRRSL ASRRSLINMV LDHVEDMEER LDDSSEAKGP EDYPEEGVEE SSGEASKYTE 1020
EDPSGETLSS ENKSSWLMTS KPSALAQETS LGAPEPLSGE QLVGSPQDKA AEATNDYETL 1080
VKRGKELKEC GKIQEALNCL VKALDIKSAD PEVMLLTLSL YKQLNNN 1127 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0004386; F:helicase activity; IEA:InterPro. 
Interpro
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase.
 IPR000330; SNF2_N. 
Pfam
 PF00271; Helicase_C
 PF00176; SNF2_N 
SMART
 SM00487; DEXDc
 SM00490; HELICc 
PROSITE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER 
PRINTS