UniProt Accession

 E9PSE5_HUMAN; E9PSE5 

Genbank Protein ID

 AL512599 

Genbank Nucleotide ID

  

Protein Name

 Palmitoyl-protein thioesterase 1 

Protein Synonyms/Alias

  

Gene Name

 PPT1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
34	FYRSGQAKETIPLQE	ubiquitination	[1, 2, 3, 4]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 87 AA 

Protein Sequence

Gene Ontology

 GO:0030424; C:axon; IEA:Compara.
 GO:0030425; C:dendrite; IEA:Compara.
 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0005764; C:lysosome; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0008021; C:synaptic vesicle; IEA:Compara.
 GO:0008474; F:palmitoyl-(protein) hydrolase activity; IEA:Compara.
 GO:0008344; P:adult locomotory behavior; IEA:Compara.
 GO:0008306; P:associative learning; IEA:Compara.
 GO:0044257; P:cellular protein catabolic process; IEA:Compara.
 GO:0007625; P:grooming behavior; IEA:Compara.
 GO:0007040; P:lysosome organization; IEA:Compara.
 GO:0007269; P:neurotransmitter secretion; IEA:Compara.
 GO:0002084; P:protein depalmitoylation; IEA:Compara.
 GO:0032429; P:regulation of phospholipase A2 activity; IEA:Compara.
 GO:0007601; P:visual perception; IEA:Compara. 

Interpro

 IPR002472; Palm_thioest. 

Pfam

 PF02089; Palm_thioest 

SMART

  

PROSITE

  

PRINTS

 PR00414; PPTHIESTRASE.