CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014420
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 TGF-beta receptor type-2 
Protein Synonyms/Alias
 TGFR-2; TGF-beta type II receptor; Transforming growth factor-beta receptor type II; TGF-beta receptor type II; TbetaR-II 
Gene Name
 Tgfbr2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
230SPSWESSKPRKLMDFubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non- canonical, SMAD-independent TGF-beta signaling pathways (By similarity). 
Sequence Annotation
 DOMAIN 269 569 Protein kinase.
 NP_BIND 275 283 ATP (By similarity).
 ACT_SITE 404 404 Proton acceptor (By similarity).
 BINDING 302 302 ATP (By similarity).
 MOD_RES 573 573 Phosphoserine (By similarity).
 CARBOHYD 48 48 N-linked (GlcNAc...) (Potential).
 CARBOHYD 95 95 N-linked (GlcNAc...) (Potential).
 CARBOHYD 119 119 N-linked (GlcNAc...) (Potential).
 DISULFID 76 109 By similarity.
 DISULFID 79 96 By similarity.
 DISULFID 86 92 By similarity.
 DISULFID 102 126 By similarity.
 DISULFID 146 161 By similarity.
 DISULFID 163 168 By similarity.  
Keyword
 Alternative splicing; Apoptosis; ATP-binding; Cell membrane; Complete proteome; Differentiation; Disulfide bond; Glycoprotein; Growth regulation; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 592 AA 
Protein Sequence
MGRGLLRGLW PLHIVLWTRI ASTIPPHVPK SDVEMEAQKD ASIHLSCNRT IHPLKHFNSD 60
VMASDNGGAV KLPQLCKFCD VRLSTCDNQK SCMSNCSITA ICEKPHEVCV AVWRKNDKNI 120
TLETVCHDPK LTYHGFTLED AASPKCVMKE KKRAGETFFM CACNMEECND YIIFSEEYTT 180
SSPDLLLVII QVTGVSLLPP LGIAIAVIII FYCYRVHRQQ KLSPSWESSK PRKLMDFSDN 240
CAIILEDDRS DISSTCANNI NHNTELLPIE LDTLVGKGRF AEVYKAKLKQ NTSEQFETVA 300
VKIFPYEEYS SWKTEKDIFS DINLKHENIL QFLTAEERKT ELGKQYWLIT AFHAKGNLQE 360
YLTRHVISWE DLRKLGSSLA RGIAHLHSDH TPCGRPKMPI VHRDLKSSNI LVKNDLTCCL 420
CDFGLSLRLD PTLSVDDLAN SGQVGTARYM APEVLESRMN LENVESFKQT DVYSMALVLW 480
EMTSRCNAVG EVKDYEPPFG SKVREHPCVE SMKDSVLRDR GRPEIPSFWL NHQGIQIVCE 540
TLTECWDHDP EARLTAQCVA ERFSELEHPE RLSGRSCSQE KIPEDGSLNT TK 592 
Gene Ontology
 GO:0005901; C:caveola; ISO:MGI.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0009897; C:external side of plasma membrane; IDA:MGI.
 GO:0005887; C:integral to plasma membrane; IEA:Compara.
 GO:0043235; C:receptor complex; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0005539; F:glycosaminoglycan binding; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004702; F:receptor signaling protein serine/threonine kinase activity; IEA:InterPro.
 GO:0046332; F:SMAD binding; IDA:BHF-UCL.
 GO:0005026; F:transforming growth factor beta receptor activity, type II; IEA:InterPro.
 GO:0005024; F:transforming growth factor beta-activated receptor activity; IGI:MGI.
 GO:0032147; P:activation of protein kinase activity; IDA:MGI.
 GO:0007568; P:aging; IEA:Compara.
 GO:0007420; P:brain development; IMP:BHF-UCL.
 GO:0060434; P:bronchus morphogenesis; IMP:MGI.
 GO:0051216; P:cartilage development; IMP:UniProtKB.
 GO:0007182; P:common-partner SMAD protein phosphorylation; IEA:Compara.
 GO:0048565; P:digestive tract development; IEA:Compara.
 GO:0007566; P:embryo implantation; IEA:Compara.
 GO:0048701; P:embryonic cranial skeleton morphogenesis; IMP:BHF-UCL.
 GO:0035162; P:embryonic hemopoiesis; IMP:BHF-UCL.
 GO:0007369; P:gastrulation; IMP:MGI.
 GO:0007507; P:heart development; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0002088; P:lens development in camera-type eye; IMP:MGI.
 GO:1990086; P:lens fiber cell apoptotic process; IDA:MGI.
 GO:0060463; P:lung lobe morphogenesis; IMP:MGI.
 GO:0060443; P:mammary gland morphogenesis; IMP:MGI.
 GO:0043011; P:myeloid dendritic cell differentiation; IMP:MGI.
 GO:0060044; P:negative regulation of cardiac muscle cell proliferation; IEA:Compara.
 GO:0031100; P:organ regeneration; IEA:Compara.
 GO:0060021; P:palate development; IMP:BHF-UCL.
 GO:0060389; P:pathway-restricted SMAD protein phosphorylation; IEA:Compara.
 GO:0001569; P:patterning of blood vessels; IMP:MGI.
 GO:0018105; P:peptidyl-serine phosphorylation; IEA:Compara.
 GO:0018107; P:peptidyl-threonine phosphorylation; IEA:Compara.
 GO:0002663; P:positive regulation of B cell tolerance induction; IMP:MGI.
 GO:0010634; P:positive regulation of epithelial cell migration; IMP:MGI.
 GO:0002053; P:positive regulation of mesenchymal cell proliferation; IMP:BHF-UCL.
 GO:0051138; P:positive regulation of NK T cell differentiation; IMP:MGI.
 GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IEA:Compara.
 GO:0043415; P:positive regulation of skeletal muscle tissue regeneration; IEA:Compara.
 GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Compara.
 GO:0002666; P:positive regulation of T cell tolerance induction; IMP:MGI.
 GO:0002651; P:positive regulation of tolerance induction to self antigen; IMP:MGI.
 GO:0006898; P:receptor-mediated endocytosis; IEA:Compara.
 GO:0070723; P:response to cholesterol; IDA:BHF-UCL.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0043627; P:response to estrogen stimulus; IEA:Compara.
 GO:0009749; P:response to glucose stimulus; IEA:Compara.
 GO:0009612; P:response to mechanical stimulus; IEA:Compara.
 GO:0007584; P:response to nutrient; IEA:Compara.
 GO:0023014; P:signal transduction by phosphorylation; IEA:GOC.
 GO:0007224; P:smoothened signaling pathway; IMP:MGI.
 GO:0060440; P:trachea formation; IMP:MGI.
 GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:InterPro.
 GO:0001570; P:vasculogenesis; IMP:BHF-UCL.
 GO:0042060; P:wound healing; IEA:Compara. 
Interpro
 IPR000333; Activin_II/TGFBeta-II_recpt.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR008271; Ser/Thr_kinase_AS.
 IPR017194; Transform_growth_fac-b_typ-2.
 IPR015013; Transforming_GF_b_rcpt_2_ecto. 
Pfam
 PF08917; ecTbetaR2
 PF00069; Pkinase 
SMART
  
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS
 PR00653; ACTIVIN2R.