UniProt Accession

 LPP3_MOUSE; Q99JY8; Q3TVM4; Q3TXR7; Q8BTB7 

Genbank Protein ID

 AK159136; AK160056; BC005558 

Genbank Nucleotide ID

 BAE34848.1; BAE35594.1; AAH05558.1 

Protein Name

 Lipid phosphate phosphohydrolase 3 

Protein Synonyms/Alias

 PAP2-beta; Phosphatidate phosphohydrolase type 2b; Phosphatidic acid phosphatase 2b; PAP-2b; PAP2b 

Gene Name

 Ppap2b 

Gene Synonyms/Alias

 Lpp3 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
8	MQSYKYDKAIVPESK	ubiquitination	[1]
15	KAIVPESKNGGSPAL	ubiquitination	[1]
74	YCNDESIKYPLKVSE	acetylation	[2, 3]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P) (By similarity). Essential to the formation of the chorioallantoic placenta and extraembryonic vasculature. Also mediates gastrulation and axis formation, probably by regulating the Wnt signaling pathway. 

Sequence Annotation

 MOD_RES 19 19 Phosphoserine (By similarity).
 MOD_RES 298 298 Phosphoserine (By similarity).
 CARBOHYD 171 171 N-linked (GlcNAc...) (Potential).  

Keyword

 Complete proteome; Developmental protein; Direct protein sequencing; Endoplasmic reticulum; Glycoprotein; Hydrolase; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 312 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005178; F:integrin binding; IDA:MGI.
 GO:0042577; F:lipid phosphatase activity; IMP:MGI.
 GO:0008195; F:phosphatidate phosphatase activity; IEA:EC.
 GO:0001568; P:blood vessel development; IMP:MGI.
 GO:0060070; P:canonical Wnt receptor signaling pathway; IDA:BHF-UCL.
 GO:0044329; P:canonical Wnt receptor signaling pathway involved in positive regulation of cell-cell adhesion; IEA:Compara.
 GO:0044328; P:canonical Wnt receptor signaling pathway involved in positive regulation of endothelial cell migration; IEA:Compara.
 GO:0044330; P:canonical Wnt receptor signaling pathway involved in positive regulation of wound healing; IEA:Compara.
 GO:0016337; P:cell-cell adhesion; IDA:MGI.
 GO:0001702; P:gastrulation with mouth forming second; IMP:MGI.
 GO:0034109; P:homotypic cell-cell adhesion; IEA:Compara.
 GO:0001933; P:negative regulation of protein phosphorylation; IDA:BHF-UCL.
 GO:0006644; P:phospholipid metabolic process; IMP:MGI.
 GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:MGI.
 GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IDA:BHF-UCL.
 GO:0050821; P:protein stabilization; IDA:BHF-UCL.
 GO:0030111; P:regulation of Wnt receptor signaling pathway; IDA:MGI. 

Interpro

 IPR016118; P_Acid_Pase/Cl_peroxidase_N.
 IPR000326; P_Acid_Pase_2/haloperoxidase. 

Pfam

 PF01569; PAP2 

SMART

 SM00014; acidPPc 

PROSITE

  

PRINTS