CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029981
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Clathrin light chain A 
Protein Synonyms/Alias
 Clathrin, light polypeptide (Lca), isoform CRA_c 
Gene Name
 Clta 
Gene Synonyms/Alias
 mCG_16456 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
112SEPESIRKWREEQTEubiquitination[1]
141EWKEKAIKELEEWYAubiquitination[1]
211RLCDFNPKSSKQAKDacetylation[2]
211RLCDFNPKSSKQAKDubiquitination[1]
230RSVLISLKQAPLVH*acetylation[2, 3, 4]
230RSVLISLKQAPLVH*ubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 236 AA 
Protein Sequence
MAELDPFGAP AGAPGGPALG NGVAGAGEED PAAAFLAQQE SEIAGIENDE AFAILDGGAP 60
GPQPHGEPPG GPDAVDGVMN GEYYQESNGP TDSYAAISEV DRLQSEPESI RKWREEQTER 120
LEALDANSRK QEAEWKEKAI KELEEWYARQ DEQLQKTKAN NRVADEAFYK QPFADLIGYV 180
AAEEAFVNDI DESSPGTEWE RVARLCDFNP KSSKQAKDVS RMRSVLISLK QAPLVH 236 
Gene Ontology
 GO:0030132; C:clathrin coat of coated pit; IEA:InterPro.
 GO:0030130; C:clathrin coat of trans-Golgi network vesicle; IEA:InterPro.
 GO:0005198; F:structural molecule activity; IEA:InterPro.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0016192; P:vesicle-mediated transport; IEA:InterPro. 
Interpro
 IPR000996; Clathrin_L-chain. 
Pfam
 PF01086; Clathrin_lg_ch 
SMART
  
PROSITE
 PS00224; CLATHRIN_LIGHT_CHN_1
 PS00581; CLATHRIN_LIGHT_CHN_2 
PRINTS