CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002848
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fructose-bisphosphate aldolase C 
Protein Synonyms/Alias
 Brain-type aldolase 
Gene Name
 ALDOC 
Gene Synonyms/Alias
 ALDC 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
28LRIVAPGKGILAADEubiquitination[1, 2, 3]
42ESVGSMAKRLSQIGVubiquitination[2, 4]
108KGIVVGIKVDKGVVPubiquitination[2]
111VVGIKVDKGVVPLAGubiquitination[1, 2, 3]
140ERCAQYKKDGADFAKubiquitination[1]
147KDGADFAKWRCVLKIubiquitination[1, 5]
153AKWRCVLKISERTPSubiquitination[2]
200PDGDHDLKRCQYVTEubiquitination[1]
208RCQYVTEKVLAAVYKubiquitination[1, 5]
330AATEEFIKRAEVNGLubiquitination[1, 2, 3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
 ACT_SITE 188 188 Proton acceptor (By similarity).
 ACT_SITE 230 230 Schiff-base intermediate with
 BINDING 56 56 Substrate.
 BINDING 147 147 Substrate.
 MOD_RES 39 39 Phosphoserine (By similarity).
 MOD_RES 111 111 N6-acetyllysine.
 MOD_RES 119 119 Phosphothreonine (By similarity).  
Keyword
 3D-structure; Acetylation; Complete proteome; Glycolysis; Lyase; Phosphoprotein; Reference proteome; Schiff base. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 364 AA 
Protein Sequence
MPHSYPALSA EQKKELSDIA LRIVAPGKGI LAADESVGSM AKRLSQIGVE NTEENRRLYR 60
QVLFSADDRV KKCIGGVIFF HETLYQKDDN GVPFVRTIQD KGIVVGIKVD KGVVPLAGTD 120
GETTTQGLDG LSERCAQYKK DGADFAKWRC VLKISERTPS ALAILENANV LARYASICQQ 180
NGIVPIVEPE ILPDGDHDLK RCQYVTEKVL AAVYKALSDH HVYLEGTLLK PNMVTPGHAC 240
PIKYTPEEIA MATVTALRRT VPPAVPGVTF LSGGQSEEEA SFNLNAINRC PLPRPWALTF 300
SYGRALQASA LNAWRGQRDN AGAATEEFIK RAEVNGLAAQ GKYEGSGEDG GAAAQSLYIA 360
NHAY 364 
Gene Ontology
 GO:0030424; C:axon; IEA:Compara.
 GO:0005856; C:cytoskeleton; IC:BHF-UCL.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0008092; F:cytoskeletal protein binding; IDA:BHF-UCL.
 GO:0004332; F:fructose-bisphosphate aldolase activity; IDA:UniProtKB.
 GO:0007568; P:aging; IEA:Compara.
 GO:0006915; P:apoptotic process; IEA:Compara.
 GO:0030388; P:fructose 1,6-bisphosphate metabolic process; IDA:UniProtKB.
 GO:0006000; P:fructose metabolic process; TAS:ProtInc.
 GO:0006094; P:gluconeogenesis; TAS:Reactome.
 GO:0006096; P:glycolysis; TAS:Reactome.
 GO:0031100; P:organ regeneration; IEA:Compara.
 GO:0051290; P:protein heterotetramerization; IEA:Compara.
 GO:0051289; P:protein homotetramerization; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0014070; P:response to organic cyclic compound; IEA:Compara.
 GO:0010243; P:response to organic nitrogen; IEA:Compara.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 
Interpro
 IPR000741; Aldolase_I.
 IPR013785; Aldolase_TIM. 
Pfam
 PF00274; Glycolytic 
SMART
  
PROSITE
 PS00158; ALDOLASE_CLASS_I 
PRINTS