Tag | Content |
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CPLM ID | CPLM-014699 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Leucine-rich repeat flightless-interacting protein 1 |
Protein Synonyms/Alias | LRR FLII-interacting protein 1 |
Gene Name | Lrrfip1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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105 | EASIREIKDSLAEVE | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding (By similarity). |
Sequence Annotation | REGION 479 580 DNA-binding (By similarity). MOD_RES 2 2 N-acetylthreonine (By similarity). MOD_RES 16 16 Phosphoserine (By similarity). MOD_RES 83 83 Phosphoserine (By similarity). MOD_RES 88 88 Phosphoserine (By similarity). MOD_RES 91 91 Phosphothreonine (By similarity). MOD_RES 302 302 Phosphoserine (By similarity). MOD_RES 551 551 Phosphoserine (By similarity). |
Keyword | Acetylation; Coiled coil; Complete proteome; Cytoplasm; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 738 AA |
Protein Sequence | MTSPEGAQNK EIDCLSPEAQ RLAEARLAAK RAARAEAREI RMKELERQQK EVEERPDKDF 60 AEKGSRNMPS LSAATLASLG GTSSRRGSGD TSISMDTEAS IREIKDSLAE VEEKYKKAMV 120 SNAQLDNEKT NFMYQVDTLK DMLLELEEQL AESQRQYEEK NKEFEREKHA HSILQFQFAE 180 VKEALRQREE MLEKHGIILN SEIATNGETS DTVNDVGYQA PTKITKEELN ALKAAGEGTL 240 GKAKEVEVKK EIVEKVGQRE TLQDSEQEQP KLNTGKDCVD RGVLHPGEKA ENQRPVEDSA 300 LSPGPLAGAK CEQEVQSQDQ ENTSILKSPE QIESHEVTNK SDSRDSNSPE PSSCRGGLDS 360 EVSGPTALGI KNQSENSMDS QGKENQEDLG KGSFEPRPDH VLGQTPEIDK VSCTDSRGTG 420 GNHLEDVVQA GDTIVEDQVG TMASAEQSKS MENHIGRSLN DGLGQSSERE LAHEAAELEE 480 ALTQSSQAGG ENTVTEAEDA AVRDEKPLQA DVQATPAAPT VQSGHQDTTG PGSTDTKHTS 540 PHAKERNKAK SEQQAEALDS PQKKTKNKKK KNKKKKAAAP METCKDANEE SSCQDPDVGD 600 GEEEERVQAT DKKWAAETPE LKEDPQSRPS GKQNDAEEDS GPAEGPTDVL DQNSLQCADG 660 DISPVGRKGP QRDASQIGGE EGLVPSQHPG QADEKGIEGH SVDNSDLSGE LGGFNSESGE 720 QAREEVGNSK SKEDCTMS 738 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0003677; F:DNA binding; ISS:UniProtKB. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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