UniProt Accession

 DDAH2_RAT; Q6MG60 

Genbank Protein ID

 BX883045; BC086443; BC097930 

Genbank Nucleotide ID

 CAE83986.1; AAH86443.1; AAH97930.1 

Protein Name

 N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 

Protein Synonyms/Alias

 DDAH-2; Dimethylarginine dimethylaminohydrolase 2; DDAHII; Dimethylargininase-2 

Gene Name

 Ddah2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
40	LPALDLAKAQREHGV	acetylation	[1]
51	EHGVLGGKLRQRLGL	acetylation	[1]
105	PEVDGVRKALQDLGL	ubiquitination	[2]
194	GSSEAAQKAVRAMAA	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation (By similarity). 

Sequence Annotation

 ACT_SITE 171 171 Proton donor (By similarity).
 ACT_SITE 276 276 Nucleophile (Potential).  

Keyword

 Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Mitochondrion; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 285 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0016597; F:amino acid binding; IDA:RGD.
 GO:0016403; F:dimethylargininase activity; ISS:UniProtKB.
 GO:0006525; P:arginine metabolic process; IDA:RGD.
 GO:0000052; P:citrulline metabolic process; ISS:UniProtKB. 

Interpro

 IPR003198; Amidino_trans. 

Pfam

 PF02274; Amidinotransf 

SMART

  

PROSITE

  

PRINTS