CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029226
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 E3 ubiquitin-protein ligase Mdm2 
Protein Synonyms/Alias
 Mdm2 
Gene Name
 mdm2 
Gene Synonyms/Alias
 MDM2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
45LKSVGAQKDTYTMKEubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 256 AA 
Protein Sequence
MCNTNMSVPT DGAVTTSQIP ASEQETLVRP KPLLLKLLKS VGAQKDTYTM KEVLFYLGQY 60
IMTKRLYDEK QQHIVYCSND LLGDLFGVPS FSVKEHRKIY TMIYRNLVVV NQQESSDSGT 120
SVSENRCHLE GGSDQKDLVQ ELQEEKPSSS HLVSRPSTSS RRRAISETEE NSDELSGERQ 180
RKRHKSDSIS LSFDESLALC VIREICCERS SSSESTGTPS NPDLDAGVYQ VTVYQAGESD 240
TDSFEEDPEI SLADYW 256 
Gene Ontology
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0043066; P:negative regulation of apoptotic process; IEA:InterPro.
 GO:0071157; P:negative regulation of cell cycle arrest; IEA:InterPro.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:InterPro.
 GO:0016567; P:protein ubiquitination; IEA:InterPro. 
Interpro
 IPR015459; MDM2_E3_ligase.
 IPR016495; p53_neg-reg_MDM_2/4.
 IPR003121; SWIB_MDM2_domain. 
Pfam
 PF02201; SWIB 
SMART
  
PROSITE
  
PRINTS