CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016702
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Prolyl endopeptidase-like 
Protein Synonyms/Alias
 Prolylendopeptidase-like 
Gene Name
 Prepl 
Gene Synonyms/Alias
 Kiaa0436 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
6**MDAFEKVRTRLETubiquitination[1]
44GCCLVRSKDEEADSDubiquitination[1]
337TYKFAEGKLFEETGHubiquitination[1]
350GHEDPITKTSRVLRIubiquitination[1]
633TDAFEALKKYLKF**ubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Probable serine peptidase whose precise substrate specificity remains unclear. Does not cleave peptides after a arginine or lysine residue (By similarity). 
Sequence Annotation
 ACT_SITE 557 557 Charge relay system (By similarity).
 ACT_SITE 643 643 Charge relay system (By similarity).
 ACT_SITE 688 688 Charge relay system (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Hydrolase; Protease; Reference proteome; Serine protease. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 725 AA 
Protein Sequence
MDAFEKVRTR LETQPQEEYE VVNAEIKHGG FVYYQEGCCL VRSKDEEADS DNYEVLFNLE 60
ELKLDQPFID CIRVAPDEKY VAAKIRTEDS ETSTLVVVKL SDQPVMEASF PNVSSFEWVK 120
DEEDEDVLFY TFQRNLRCHD VYRATFGDNK RNERFYTEKD PSYFVFLYLT KDSRFLTLNI 180
MNKTTSEVWL IDGLSPWDPP VLIQKRIHGM LYYVEHRDDE LYILTNVGEP TEFKLMRTAA 240
DAPAIMNWDL FFTMKRNTKV VDLDMFKDHC VLFLKHSNLL YVNVIGLADD SVRSLKLPPW 300
ACGFIMDTNS DPKNCPFQLC SPIRPPKYYT YKFAEGKLFE ETGHEDPITK TSRVLRIEAK 360
SKDGKLVPMT VFHKTDSEDL QRKPLLVHVY GAYGMDLKMN FRPEKRVLVD DGWILAYCHV 420
RGGGELGLQW HADGRLTKKL NGLADLVACI KTLHSQGFSQ PSLTTLSAFS AGGVLVGALC 480
NSKPELLRAV TLEAPFLDVL NTMLDTTLPL TLEELEEWGN PSSDEKHKNY IKRYCPCQNI 540
KPQHYPSVHI TAYENDERVP LKGIVNYTEK LKEAVAEHTK GAGEGYQPPN IILDIQPGGN 600
HVIEDSHKKI TTQMKFLYEE LGLDSTDAFE ALKKYLKF 638 
Gene Ontology
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 
Interpro
 IPR001375; Peptidase_S9.
 IPR002470; Peptidase_S9A.
 IPR004106; Peptidase_S9A_B_C_N. 
Pfam
 PF00326; Peptidase_S9
 PF02897; Peptidase_S9_N 
SMART
  
PROSITE
 PS00708; PRO_ENDOPEP_SER 
PRINTS
 PR00862; PROLIGOPTASE.