UniProt Accession

 NFUA_ECOLI; P63020; P46847; Q2M779 

Genbank Protein ID

 U18997; U00096; AP009048 

Genbank Nucleotide ID

 AAA58212.1; AAC76439.1; BAE77877.1 

Protein Name

 Fe/S biogenesis protein NfuA 

Protein Synonyms/Alias

  

Gene Name

 nfuA 

Gene Synonyms/Alias

 gntY; yhgI; b3414; JW3377 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
14	AAQAHFAKLLANQEE	acetylation	[1]
165	TLKEGIEKQLLNEFP	acetylation	[1]
175	LNEFPELKGVRDLTE	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Involved in iron-sulfur cluster biogenesis under severe conditions such as iron starvation or oxidative stress. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. Required for E.coli to sustain oxidative stress and iron starvation. Also necessary for the use of extracellular DNA as the sole source of carbon and energy. 

Sequence Annotation

 METAL 149 149 Iron-sulfur (4Fe-4S) (Potential).
 METAL 152 152 Iron-sulfur (4Fe-4S) (Potential).  

Keyword

 4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Reference proteome; Stress response. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 191 AA 

Protein Sequence

Gene Ontology

 GO:0051539; F:4 iron, 4 sulfur cluster binding; IDA:EcoCyc.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0015976; P:carbon utilization; IMP:EcoCyc.
 GO:0010106; P:cellular response to iron ion starvation; IMP:EcoCyc.
 GO:0016226; P:iron-sulfur cluster assembly; IDA:EcoliWiki.
 GO:0051604; P:protein maturation; IEA:HAMAP.
 GO:0006979; P:response to oxidative stress; IMP:EcoCyc. 

Interpro

 IPR017726; Fe/S_biogenesis_protein_NfuA.
 IPR000361; FeS_biogenesis.
 IPR001075; NIF_FeS_clus_asmbl_NifU_C. 

Pfam

 PF01521; Fe-S_biosyn
 PF01106; NifU 

SMART

  

PROSITE

  

PRINTS