UniProt Accession

 SFH5_YEAST; P47008; D6VW40; Q6Q535 

Genbank Protein ID

 X87371; Z49420; AY558583; BK006943 

Genbank Nucleotide ID

 CAA60810.1; CAA89440.1; AAS56909.1; DAA08656.1 

Protein Name

 Phosphatidylinositol transfer protein SFH5 

Protein Synonyms/Alias

 PITP SFH5; SEC14 homolog 5 

Gene Name

 SFH5 

Gene Synonyms/Alias

 YJL145W; J0644 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
17	QVFDKLKKAIPGIIK	ubiquitination	[1]
50	LTQEEVDKYYDEKIA	ubiquitination	[1]
143	ELFQNVDKFVRYRIG	acetylation	[2]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane. 

Sequence Annotation

 DOMAIN 100 266 CRAL-TRIO.  

Keyword

 Complete proteome; Cytoplasm; Endoplasmic reticulum; Lipid transport; Membrane; Microsome; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 294 AA 

Protein Sequence

Gene Ontology

 GO:0032541; C:cortical endoplasmic reticulum; IDA:SGD.
 GO:0005829; C:cytosol; IDA:SGD.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0005886; C:plasma membrane; IDA:SGD.
 GO:0008526; F:phosphatidylinositol transporter activity; IDA:SGD.
 GO:0043001; P:Golgi to plasma membrane protein transport; IGI:SGD.
 GO:0046488; P:phosphatidylinositol metabolic process; IGI:SGD.
 GO:2000114; P:regulation of establishment of cell polarity; IGI:SGD.
 GO:0017157; P:regulation of exocytosis; IGI:SGD. 

Interpro

 IPR001251; CRAL-TRIO_dom.
 IPR011074; CRAL/TRIO_N_dom. 

Pfam

 PF00650; CRAL_TRIO
 PF03765; CRAL_TRIO_N 

SMART

 SM00516; SEC14 

PROSITE

 PS50191; CRAL_TRIO 

PRINTS