CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041062
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 E3 ubiquitin-protein ligase HECTD1 
Protein Synonyms/Alias
  
Gene Name
 Hectd1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
255SGPSSACKPGRSTTGubiquitination[1]
1272LVRSQVLKYMVPGARubiquitination[1]
1371VKNNCPDKTSAAAGSubiquitination[1]
1754EEEEYETKGGRRRAWubiquitination[1]
1768WDDDYVLKRQFSALVubiquitination[1]
1919DLITYLQKNADAAFLubiquitination[1]
2268LVDLPISKPFFKLMCacetylation[2]
2268LVDLPISKPFFKLMCubiquitination[1]
2280LMCMGDIKSNMSKLIubiquitination[1]
2285DIKSNMSKLIYESRGubiquitination[1]
2364ARFLKEIKDLAIKRRubiquitination[1]
2565PRLTVVRKVDATDASubiquitination[1]
2605LLAATMEKGFHLN**ubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
  
Sequence Annotation
  
Keyword
 ANK repeat; Complete proteome; Ligase; Reference proteome; Repeat; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2610 AA 
Protein Sequence
MADVDPDTLL EWLQMGQGDE RDMQLIALEQ LCMLLLMSDN VDRCFETCPP RTFLPALCKI 60
FLDESAPDNV LEVTARAITY YLDVSAECTR RIVGVDGAIK ALCNRLVVVE LNNRTSRDLA 120
EQCVKVLELI CTRESGAVFE AGGLNCVLTF IRDSGHLVHK DTLHSAMAVV SRLCGKMEPQ 180
DSSLEICVES LSSLLKHEDH QVSDGALRCF ASLADRFTRR GVDPAPLAKH GLTEELLSRM 240
AAAGGTVSGP SSACKPGRST TGAPSAAADS KLSNQVSTIV SLLSTLCRGS PLVTHDLLRS 300
ELPDSIESAL QGDERCVLDT MRLVDLLLVL LFEGRKALPK SSAGSTGRIP GLRRLDSSGE 360
RSHRQLIDCI RSKDTDALID AIDTGAFEVN FMDDVGQTLL NWASAFGTQE MVEFLCERGA 420
DVNRGQRSSS LHYAACFGRP QVAKTLLRHG ANPDLRDEDG KTPLDKARER GHSEVVAILQ 480
SPGDWMCPVN KGDDKKKKDT NKDEEECNEP RGDPEMAPLY LKRLLPVFAQ TFQHTMLPSI 540
RKASLALIRK MIHFCSEALL KEVCDSDVGH NLPTTLVEIT ATVLDQEDDD DGHLLALQII 600
RDLVDKGGDI FLDQLARLGV ISKVSALAGP SSDDENEEES KPEKEDEPQE DAKELQQGKP 660
YHWRDWSIIR GRDCLYIWSD AAALELSNGS NGWFRFILDG KLATMYSSGS PEGGSDSSES 720
RSEFLEKLQR ARGQVKPSTS SQPILSAPGP TKLTVGNWSL TCLKEGEIAI HNSDGQQATI 780
LKEDLPGFVF ESNRGTKHSF TAETSLGSEF VTGWTGKRGR KLKSKLEKTK QKVRTMARDL 840
YDDHFKAVES MPRGVVVTLR NIATQLESSW ELHTNRQCIE GENTWRDLMK TALENLIVLL 900
KDENTISPYE MCSSGLVQAL LTVLNNSIDL DMKQDCSQLV ERINVFKTAF SESEDDESRP 960
AVALIRKLIA VLESIERLPL HLYDTPGSTY NLQILTRRLR FRLERAPGET SLIDRTGRML 1020
KMEPLATVES LEQYLLKMVA KQWYDFDRSS FVFVRKLREG QNFIFRHQHD FDENGIIYWI 1080
GTNAKTAYEW VNPAAYGLVV VTSSEGRNLP YGRLEDILSR DNSALNCHSN DDKNAWFAID 1140
LGVWVIPSAY TLRHARGYGR SALRNWVFQV SKDGQNWTSL YTHVDDCSLN EPGSTATWPL 1200
DPAKDEKQGW RHVRLKQMGK NASGQTHYLS LSGFELYGTV NGVCEDQLGK AAKEAEANLR 1260
RQRRLVRSQV LKYMVPGARV IRGLDWKWRD QDGSPQGEGT VTGELHNGWI DVTWDAGGSN 1320
SYRMGAEGKF DLKLAPGYDP DTVASPKPVS STVSGTTQSW SSLVKNNCPD KTSAAAGSSS 1380
RKGSSSSVCS VASSSDISLA STKTERRSEI VMEHSIVSGA DVHEPIVVLS SAENVPQTEV 1440
GSSSSASTST LTAETGSENA ERKLGPDSSV RAPGESSAIS MGIVSVSSPD VSSVSELTNK 1500
EAASQRPLSS SASNRLSVSS LLAAGAPMSS SASVPNLSSR ETSSLESFVR RVANIARTNA 1560
TNNMNLSRSS SDNNTNTLGR NVMSTATSPL MGAQSFPNLT TPGTTSTVTM STSSVTSSSN 1620
VATATTVLSV GQSLSNTLTT SLTSTSSESD TGQEAEYSLY DFLDSCRAST LLAELDDDED 1680
LPEPDEEDDE NEDDNQEDQE YEEVMILRRP SLQRRAGSRS DVTHHVVTSQ LPQVPSGAGS 1740
RPVGEQEEEE YETKGGRRRA WDDDYVLKRQ FSALVPAFDP RPGRTNVQQT TDLEIPPPGT 1800
PHSELLEEVE CTPSPRLALT LKVTGLGTTR EVELPLTNFR STIFYYVQKL LQLSCNGNVK 1860
SDKLRRIWEP TYTIMYREMK DSDKEKENGK MGCWSIEHVE QYLGTDELPK NDLITYLQKN 1920
ADAAFLRHWK LTGTNKSIRK NRNCSQLIAA YKDFCEHGTK SGLNQGAISS LQSSDILNLT 1980
KEQPQAKAGN GQSPCGVEDV LQLLRILYIV ASDPYSRISQ EDGDEQPQFT FPPDEFTSKK 2040
ITTKILQQIE EPLALASGAL PDWCEQLTSK CPFLIPFETR QLYFTCTAFG ASRAIVWLQN 2100
RREATVERTR TTSSVRRDDP GEFRVGRLKH ERVKVPRGES LMEWAENVMQ IHADRKSVLE 2160
VEFLGEEGTG LGPTLEFYAL VAAEFQRTDL GTWLCDDNFP DDESRHVDLG GGLKPPGYYV 2220
QRSCGLFTAP FPQDSDELER ITKLFHFLGI FLAKCIQDNR LVDLPISKPF FKLMCMGDIK 2280
SNMSKLIYES RGDRDLHCTE SQSEASTEEG HDSLSVGSFE EDSKSEFILD PPKPKPPAWF 2340
NGILTWEDFE LVNPHRARFL KEIKDLAIKR RQILGNKSLS EDEKNTKLQE LVLRNPSGSG 2400
PPLSIEDLGL NFQFCPSSRI YGFTAVDLKP SGEDEMITMD NAEEYVDLMF DFCMHTGIQK 2460
QMEAFRDGFN KVFPMEKLSS FSHEEVQMIL CGNQSPSWAA EDIINYTEPK LGYTRDSPGF 2520
LRFVRVLCGM SSDERKAFLQ FTTGCSTLPP GGLANLHPRL TVVRKVDATD ASYPSVNTCV 2580
HYLKLPEYSS EEIMRERLLA ATMEKGFHLN 2610 
Gene Ontology
 GO:0005737; C:cytoplasm; IBA:RefGenome.
 GO:0005634; C:nucleus; IBA:RefGenome.
 GO:0046872; F:metal ion binding; IEA:InterPro.
 GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome.
 GO:0001843; P:neural tube closure; IMP:MGI.
 GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR008979; Galactose-bd-like.
 IPR000569; HECT.
 IPR010606; Mib_Herc2.
 IPR012919; Sad1_UNC_C. 
Pfam
 PF12796; Ank_2
 PF00632; HECT
 PF06701; MIB_HERC2
 PF07738; Sad1_UNC 
SMART
 SM00248; ANK
 SM00119; HECTc 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT
 PS50237; HECT
 PS51416; MIB_HERC2 
PRINTS